Intake of Coffee In Ameliorated Risk of Primary Sclerosing Cholangitis

A recent study suggested that coffee and caffeine consumption may be associated to reduced risk of primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is a medical condition of inflammation and obliterative fibrosis of the bile ducts.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the study of 606 patients with primary biliary cirrhosis (PBC), 480 with primary sclerosing cholangitis (PSC), and 564 healthy volunteers acted as controls, researchers filed the following results

1. 24% of patients with PSC had never drunk coffee in compared to 16% of controls.
2. Patients with PSC also consumed fewer lifetime cups per month and spent a smaller percentage of their lifetime drinking coffee compared to healthy adults.

Base on this information, Dr.Lammert C, the lead author opinionated, coffee consumption is lower among patients with PSC, compared with controls.


Additionally, In patients with PSC, recruited from Oslo University Hospital Rikshospitalet in Norway through 2011, randomly chosen from the Norwegian Bone Marrow Donor Registry (control subjects) of 240 patients with PSC and 245 control subjects also indicated a similar conclusion as follow
1. In comparison to control, PSC patients showed a lower daily drinking coffee habit as the time of study and at the age of 18 years observed in men.
2. Ever daily coffee drinker at the age of 18 years was independently and negatively associated with PSC.

These results showed that coffee intake may have a profound effect on protection against the development of PSC.

The finding evidence demonstrated that coffee and caffeine consumption may have a significant effect on the attenuated risk of primary sclerosing cholangitis developing, but further large and multi centers studies are necessary to validate this claim.



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Sources
(1) Reduced coffee consumption among individuals with primary sclerosing cholangitis but not primary biliary cirrhosis by Lammert C1, Juran BD1, Schlicht E1, Xie X2, Atkinson EJ2, de Andrade M2, Lazaridis KN3.(PubMed)