Green Tea in Reduced Symptoms Severity and Treatment of Osteoarthritis

Osteoarthritis (OA), a form of arthritis, is a condition characterized by aging progression of wear and tear on a joint, affecting over 25 million people in the United States in alone

In a randomized open-label active-controlled clinical trial of 50 adults with osteoarthritis of knee allocated to receive the green tea extract (in dosage form of the tablet) plus diclofenac tablet as "intervention group"; or: diclofenac tablet alone as "control group" for a period of four weeks, combination-treated group exerted a significant improvement of physical function in compared to control.

The treatment group also expressed similar progress in pain reduction during knee joint physical function in adults with osteoarthritis as in the control group.



Additionally, in the compared the effect of curcuminoids extract, hydrolyzed collagen, and green tea extract, in chondrocytes culture cell, researchers found that a combination of all components score an enormous expression of reduced production of pro-inflammatory cytokines through various mechanisms, including ameliorated free radical elucidation.



Furthermore, in the support of the above differentiation, the study in the investigation of posttraumatic osteoarthritis (OA) mouse model tested with EGCG against the progression of OA and relieve OA-associated pain, suggested that EGCG-treated mice promoted cartilage production against Safranin O, staining of the knee joint cartilage loss and cartilage erosion in compared to control group with no treatment.
Importantly, the cartilage of treated mice also displays a significant reduction of the gene in regulated degeneration of connective tissue as well as pathways involved promotional of tissue inflammation.

Additionally, the pain score of treated mice also exhibited a significant enhancement in the compared control group.

Taking together, there is no doubt that the green tea process a therapeutic and integrated form for the prevention and treatment of symptoms of pain as well as improved physical activity of OA patients through protection against cartilage degeneration.


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Sources
(1)Green tea (Camellia sinensis) for patients with knee osteoarthritis: A randomized open-label active-controlled clinical trial by Hashempur MH1, Sadrneshin S2, Mosavat SH3, Ashraf A4.(PubMed)
(2) Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer by Comblain F1, Sanchez C1, Lesponne I2, Balligand M3, Serisier S2, Henrotin Y4.(PubMed)
(3) Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model by Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB.(PubMed)