Ginger, the Anti Chronic Mild Stress and Arteriosclerosis Natural Remedy

Scientists may have found a natural remedy that processes the potential to treat chronic mild stress, according to studies.

Acute stress is a natural and emotional reaction that arises in response to a terrifying or traumatic event or witnessing a traumatic event. People react to acute stress differently depending on life experiences.

Chronic stress, a medical condition is a result of a person who can not respond to emotional pressure properly, leading to traumatic stress which he or she can not control.

Untreated ongoing chronic stress has been found to exacerbate many serious health conditions, including depression, anxiety, and personality disorders.


Epidemiological studies suggested that certain physical health problems are also associated with patients with long-term stress, including heart disease, high blood pressure, abnormal heart rhythms, heart attacks, and stroke.


There are many risk factors involving the onset of chronic stress. However, job-related chronic stress has been found in most American adults in the Western world.

The American Institute of Stress in examing the chronic stress in American adults wrote, "Numerous studies show that job stress is far and away from the major source of stress for American adults and that it has escalated progressively over the past few decades. Increased levels of job stress as assessed by the perception of having little control but lots of demands have been demonstrated to be associated with increased rates of heart attack, hypertension, and other disorders".

According to the American Workplace VII statistics, 80% of workers feel stress on the job, nearly half say they need help in learning how to manage stress and 42% say their coworkers need such help.


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding natural ingredients or whole food for the treatment of chronic mild stress (CMS), a major contribution to atherosclerosis in the previous study examined the effects of 6-gingerol (6-Gin), a phenolic component of ginger (Zingiber officinale)anti chronic stress activity.

6-gingerol (6-Gin) has long been found to process numerous pharmacological properties, such as anti-inflammatory and cardioprotective effects, according to epidemiological studies.

CMS ApoE-/- mice used in the study were given a high-fat diet (HFD) to induce the development of atherosclerosis in-fed before administrating 6-Gin.



Mice were exposed to CMS for 20 weeks, at week 5, they were fed with a high-fat diet (HFD), then received 6-Gin (20 mg/kg/day, intragastrically) treatment.

CMS before application of a high-fat diet exerted a significant effect in reducing body weight gain, sucrose preference, and locomotor activity, the expression of some of the core symptoms of depression.


Furthermore, CMS mice fed with a high-fat diet (HFD) after week 5 also showed the increased plaque formation, the elevation of plasma total cholesterol, triglyceride, low-density lipoprotein cholesterin, and proinflammatory cytokines including TNF-α, IL-1β, and IL-6, all indicated the development of atherosclerotic lesions.

However, the injection of 6-Gin not only reduced the expression induced by a high-fat diet but modulated the function of enzymes activated glucose and fatty acid uptake and oxidation, catalyzed the committed step in fatty acid synthesis, produced cholesterol, and other isoprenoids, particularly the lipid synthesis in the liver tissues.

These results suggested the role of ginger in the alleviated atherosclerotic lesions and reversed the expression levels of lipid profiles and inflammatory cytokines in stressed mice.

Dr. Wang S, the lead scientist wrote, "the antiatherosclerotic effects of 6-Gin is mediated in part by the AMPK signaling pathway, which is closely associated with cholesterol synthesis and lipid accumulation".


Where AMP-activated protein kinase (AMPK) plays a key role as a master regulator of cellular energy homeostasis, in response to low glucose, hypoxia, ischemia, and heat shock.

Additionally, CMS also showed an improvement in several aspects of chronic stress on the injection of 6-Gin.

The finding clearly suggested 6-Gin attenuates arteriosclerosis in ApoE-/- mice exposed to CMS and HFD, and it may be a potential therapeutic agent for the treatment of atherosclerosis similar to that of conventional medicine.


Taken altogether, ginger processed abundantly bioactive compound 6-gingerol may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of chronic mild stress and atherosclerosis, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) 6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE-/- Mice Exposed to Chronic Mild Stress by Wang S1, Tian M2, Yang R1, Jing Y1, Chen W1, Wang J1, Zheng X1, Wang F. (PubMed)
(2) Transforming stress through awareness, education, and collaboration by AIS