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Sunday, January 29, 2012

Hormonal effects of soy and premenopausal women and men

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the study of "Hormonal effects of soy in premenopausal women and men" by
Kurzer MS., posted in US National Library of Medicine National Institutes of Health, found that
the studies in women have provided modest support for beneficial effects. One cross-sectional study showed serum estrogens to be inversely associated with soy intake. Seven soy intervention studies controlled for phase of menstrual cycle. These studies provided 32-200 mg/d of isoflavones and generally showed decreased midcycle plasma gonadotropins and trends toward increased menstrual cycle length and decreased blood concentrations of estradiol, progesterone and sex hormone-binding globulin. A few studies also showed decreased urinary estrogens and increased ratios of urinary 2-(OH) to 16alpha-(OH) and 2-(OH) to 4-(OH) estrogens. Soy and isoflavone consumption does not seem to affect the endometrium in premenopausal women, although there have been weak estrogenic effects reported in the breast.

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