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Tuesday, January 31, 2012

Soy-derived isoflavonoid and Skin aging

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the study of "Biochemical investigation and gene analysis of equol: A plant and soy-derived isoflavonoid with antiaging and antioxidant properties with potential human skin applications" by Gopaul R, Knaggs HE, Lephart ED., posted in posted in US National Library of Medicine National Institutes of Health, showed that equol significantly increased collagen, elastin (ELN), and tissue inhibitor of metalloprotease and decreased metalloproteinases (MMPs) gene expression and caused significant positive changes in skin antioxidant and antiaging genes. In hMFC, equol significantly increased collagen type I (COL1A1), whereas, 5α-DHT significantly decreased cell viability that was blocked by equol. FACS analysis showed equol and 17β-estradiol significantly stimulated COL1A1, collagen type III (COL3A1), and ELN while MMPs were significantly decreased compared with control values.

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