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Monday, January 18, 2016

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: of Polycystic Ovarian Syndrome: TCM recommended Foods for Spleen Yang deficiency - Royal jelly

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).

PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

                               Spleen yang deficiency

Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....

                      Foods for Spleen yang deficiency

Spleen yang deficiency can be managed and treated in part with a diet of fresh and cooked warming foods.

1. Royal jelly(See kidney yang deficiency for more information)
Royal jelly is produced by the worker bees and fed to bee larves for 3 days to stimulate healthy and rapid growth and life for the queen to ensure the endless production of eggs, used in traditional Chinese medicine to treat malnutrition in children(1653), cognitive decline(1654) and sarcopenia due to ageing(1655), leukopenia(1656), liver diseases(1657)(1658)(1659), ulcer(1660)(1661), bronchial asthma(1662)(1663), diabetes(1664)(1665), high blood pressure(1666)(1667), cognitive impairment(1668), functional uterine abnormality(1669) through its estrogenic activitie(1670), irregular menses(1571) and functional infertility(1672) by enhancing function of spleen, liver and kidney channels(1653).

Chemical constituent(1653)
1. Inositol
2. 6-Biopterin
3. Flavin adenine dinucleotide
4. Flavin mononucleotide
5. Kynurenine
6. Albumin
7. β and γ globulin
8. Insoluble protein
9. Acetylcholine
10. Stearin
11. Phospholipid
12. Adenine nucleotides
13. Arginine
14. Aspartic acid
15. Glutamic acid
16. Lysine
17. Proline
18. β-alanine
18. Etc.

Epidemiological studies suggested that royal jelly also displays certain metabolic syndrome effects, such as glucose tolerance(1673), anti insulin resistance(1677)(1679), anti hypertension(1677), anti-hypercholesterolemic(1654)(1675) and anti-hyperglycemic(1654)(1678), induced weight loss(1676) and reduced risk of symptoms of fatigue( 1682), depression(1683) and anxiety(1683) and complication, such as diabetes(1678), breast cancer(1684)(1685) through anti-inflammatory(1654), anti-oxidative(1654) and immune defense(1674) activities.
According to joint study by Urmia University and Kermanshah University of Medical Sciences, royal jelly also improved reproductive parameters(1680)(1681) such as testicular weight, sperm count, viability, motility, deformity, DNA integrity, chromatin quality, serum testosterone and testicular tissue MDA levels in male diabetic rats(1680).

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By addressing the Underlying Causes through Clinical Trials and Studies

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(1653) Royal bee jelly(Complementary and Alternative Healing University)
(1654) Long-term administration of Greek Royal Jelly improves spatial memory and influences the concentration of brain neurotransmitters in naturally aged Wistar male rats by Pyrzanowska J1, Piechal A1, Blecharz-Klin K1, Joniec-Maciejak I1, Graikou K2, Chinou I2, Widy-Tyszkiewicz E3.(PubMed)
(1655) Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro by Niu K1, Guo H, Guo Y, Ebihara S, Asada M, Ohrui T, Furukawa K, Ichinose M, Yanai K, Kudo Y, Arai H, Okazaki T, Nagatomi R.(PubMed)
(1656) In-depth phosphoproteomic analysis of royal jelly derived from western and eastern honeybee species by Han B1, Fang Y, Feng M, Lu X, Huo X, Meng L, Wu B, Li J.(PubMed)
(1657) Royal jelly modulates oxidative stress and apoptosis in liver and kidneys of rats treated with cisplatin by Karadeniz A1, Simsek N, Karakus E, Yildirim S, Kara A, Can I, Kisa F, Emre H, Turkeli M.(PubMed)
(1658) Serum and liver tissue bio-element levels, and antioxidant enzyme activities in carbon tetrachloride-induced hepatotoxicity: protective effects of royal jelly by Cemek M1, Yılmaz F, Büyükokuroğlu ME, Büyükben A, Aymelek F, Ayaz A.(PubMed)
(1659) The effects of royal jelly on liver damage induced by paracetamol in mice by Kanbur M1, Eraslan G, Beyaz L, Silici S, Liman BC, Altinordulu S, Atasever A.(PubMed)
(1660) The efficacy of topical royal jelly on healing of diabetic foot ulcers: a double-blind placebo-controlled clinical trial by Siavash M1, Shokri S, Haghighi S, Shahtalebi MA, Farajzadehgan Z.(PubMed)
(1661) [Influence of honey, royal jelly and propolis on accelerating acetate healing of experimental gastric ulcers in rats].[Article in Russian] by Belostotskiĭ NI, Kas'ianenko VI, Dubtsova EA, Lazebnik LB.(PubMed)
(1662) Complementary and alternative medicine in children with asthma by Orhan F1, Sekerel BE, Kocabas CN, Sackesen C, Adalioglu G, Tuncer A.(PubMed)
(1663) Asthma following royal jelly by Harwood M, Harding S, Beasley R, Frankish PD.(PubMed)
(1664) Effects of royal jelly supplementation on body weight and dietary intake in type 2 diabetic females by Pourmoradian S1, Mahdavi R2, Mobasseri M3, Faramarzi E1, Mobasseri M4.(PubMed)
(1665) Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial by Pourmoradian S1, Mahdavi R, Mobasseri M, Faramarzi E, Mobasseri M.(PubMed)
(1666) Antihypertensive activities of royal jelly protein hydrolysate and its fractions in spontaneously hypertensive rats by Takaki-Doi S1, Hashimoto K, Yamamura M, Kamei C.(PubMed)
(1667) Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats by Tokunaga KH1, Yoshida C, Suzuki KM, Maruyama H, Futamura Y, Araki Y, Mishima S.(PubMed)
(1668) Effect of Memo®, a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment by Yakoot M1, Salem A, Helmy S.(PubMed)
(1669) Raw drone milk of honeybees elicits uterotrophic effect in rats: evidence for estrogenic activity by Seres AB1, Ducza E, Báthori M, Hunyadi A, Béni Z, Dékány M, Gáspár R.(PubMed)
(1670) Royal jelly has estrogenic effects in vitro and in vivo by Mishima S1, Suzuki KM, Isohama Y, Kuratsu N, Araki Y, Inoue M, Miyata T.(PubMed)
(1671) Effect of Royal Jelly on premenstrual syndrome among Iranian medical sciences students: a randomized, triple-blind, placebo-controlled study by Taavoni S1, Barkhordari F2, Goushegir A3, Haghani H4.(PubMed)
(1672) Towards a molecular definition of worker sterility: differential gene expression and reproductive plasticity in honey bees by Thompson GJ1, Kucharski R, Maleszka R, Oldroyd BP.(PubMed)
(1673) Effect of royal jelly ingestion for six months on healthy volunteers by Hiroyuki Morita,1 Takahide Ikeda,1 Kazuo Kajita,1 Kei Fujioka,1 Ichiro Mori,1 Hideyuki Okada,1 Yoshihiro Uno,1 and Tatsuo Ishizuka.(PubMed)
(1674) Immune defense and antibacterial activity In-depth phosphoproteomic analysis of royal jelly derived from western and eastern honeybee species by Han B1, Fang Y, Feng M, Lu X, Huo X, Meng L, Wu B, Li J.(PubMed)
(1675) Royal jelly increases high density lipoprotein levels but in older patients only by Münstedt K, Henschel M, Hauenschild A, von Georgi R.(PubMed)
(1676) Effects of Royal Jelly Supplementation on Body Weight and Dietary Intake in Type 2 Diabetic Females by Samira Pourmoradian, 1 Reza Mahdavi, 2 ,* Majid Mobasseri, 3 Elnaz Faramarzi, 1 and Mehrnoosh Mobasseri(PubMed)
(1677) Royal jelly ameliorates insulin resistance in fructose-drinking rats by Zamami Y1, Takatori S, Goda M, Koyama T, Iwatani Y, Jin X, Takai-Doi S, Kawasaki H.(PubMed)
(1678) Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial by Pourmoradian S1, Mahdavi R, Mobasseri M, Faramarzi E, Mobasseri M.(PubMed)
(1679) [Effect of long-term treatment with royal jelly on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats].[Article in Japanese] by Nomura M1, Maruo N, Zamami Y, Takatori S, Doi S, Kawasaki H.(PubMed)
(1680) Study on the effect of royal jelly on reproductive parameters in streptozotocin-induced diabetic rats by Ghanbari E1, Nejati V1, Najafi G2, Khazaei M3, Babaei M2.(PubMed)
(1681) Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats by Amirshahi T1, Najafi G2, Nejati V1.(PubMed)
(1682) Antifatigue effect of fresh royal jelly in mice by Kamakura M1, Mitani N, Fukuda T, Fukushima M.(PubMed)
(1683) Antidepressant-like activity of 10-hydroxy-trans-2-decenoic Acid, a unique unsaturated Fatty Acid of royal jelly, in stress-inducible depression-like mouse model by Ito S1, Nitta Y, Fukumitsu H, Soumiya H, Ikeno K, Nakamura T, Furukawa S.(PubMed)
(1684) GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells by Okic-Djordjevic I1, Trivanovic D, Krstic J, Jaukovic A, Mojsilovic S, Santibanez JF, Terzic M, Vesovic D, Bugarski D.(PubMed)
(1685) Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells by Nakaya M1, Onda H, Sasaki K, Yukiyoshi A, Tachibana H, Yamada K.(PubMed)
(2072) Spleen, Earth
(2073) [Research on building method of spleen kidney Yang deficiency diarrhea rats model]. [Article in Chinese] by Pan X, Hu CJ, Geng YY, Zhao L, Wu WH, Wu XQ, Zhong ZD.(PubMed)
(2074) Treatment of an elderly patient with acute abdominal pain with traditional Korean medicine by Son CG1.(PubMed)
(2075) Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial by Fang Z1, Zhao J2, Shi G3, Shu Y3, Ni Y3, Wang H3, Ding L3, Lu R3, Li J3, Zhu X3, Cheng S4, Zhang X3, Liu Y5, Wang J6, Luo Y3, Fan Q3, Guo C3, Jiang T3, Wu Q3, Fan L3, Ling H3, Cui L3, Luo Y3, Yang H3, Anderson RM7.(PubMed)
(2075) Direct moxibustion to treat spleen qi and yang deficiency fatigue: a pilot study by Thorne TL1, Hanes DA2, Wild H3, Colbert A4.(PubMed)
(2076) [Clinical observation on fuzhong (supporting the middle-jiao) manipulation of tuina for infantile anorexia]. [Article in Chinese] by Wang YY, Liu XY.(PubMed)
(2077) [Effect of umbilicus moxibustion therapy on physical conditions of yang-deficiency volunteers]. [Article in Chinese] by Zhang YY1.(PubMed)
(2078) Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics by Zheng XF1, Tian JS2, Liu P3, Xing J1, Qin XM1.(PubMed)
(2079) [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model]. [Article in Chinese] by Chen L, Xiang H, Xing J, Tian JS, Qin XM, Du GH.(PubMed)
(2080) Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease by Dong Y1,2, Li Y3,4,5, Sun Y6, Mao J7, Yao F8, Tian Y9, Wang L10, Li L11, Li S12,13,14, Li J15,16,17(PubMed)
(2081) [Clinical observation on obesity and hyperlipidemia of liver qi stagnation and spleen deficiency pattern in female patients treated with combined therapy of acupuncture and tapping method]. [Article in Chinese] by Wu B, Liu ZC, Xu B.(PubMed)

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