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Wednesday, June 1, 2016

The Powerful Smoothie of Baking Soda, Sweet Potato and Orange Juice for Prevention and Treatment of Contrast-induced nephropathy

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie at least prolong and prevention of Contrast-induced nephropathy
Yield: 2 servings (about 8 ounces each)
1 1/2 cups cooked sweet potato
1 1/2 grams baking soda
1 cup of organic orange juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Contrast-induced nephropathy has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Sodium bicarbonate and Juar tea may be the next generation of natural ingredients for prevention and treatment of Skeletal Abnormalities in Conorenal syndrome.

Contrast-induced nephropathy is  meducal condition of reno dysfunction with either a greater than 25% increase of serum creatinine or an absolute increase in serum creatinine of 0.5 mg/dL increase in absolute value, within 48-72 hours of intravenous contrast administration, according to Medscape(1) caused by acute kidney injure.

Sodium bicarbonate or baking soda, bread soda, cooking soda may be used for prevention and treatment of patients acute kidney injure induced Contrast-induced nephropathy(CIN)(2). According to the National University Health System, Singapore, in a multi-centre, randomised, controlled trial, suggested that 12-hour sustained sodium chloride pre-hydration regimen was more protective than the 1-hour abbreviated SOB regimen in patients with Contrast-induced nephropathy(CIN)(3).
Dr. Navaneethan SD and colleagues at the Cleveland Clinic said, "Hydration with sodium bicarbonate decreases the incidence of contrast-induced nephropathy in comparison to hydration with normal saline without a significant difference in need for renal replacement therapy and in-hospital mortality"(4).

Antioxidant including vitamin C and E plays important role in reduced risk and treatment of patients of contrast-induced nephropathy caused by acute kidney injure or chronic kidney disease, according to the Shahid Sadoughi University of Medical Sciences(6).
Vitamin C, a water soluble vitamin found abundantly in orange in a study in comparison of
N-acetylcysteine and/or ascorbic acid versus placebo, showed that high doses of NAC plus hydration provide better protection against CIN than combination therapy of NAC and ascorbic acid plus hydration, or hydration alone(7).
Dr. Sadat U and colleagues at the Cambridge University Hospitals NHS Foundation Trust, in the review of 9 randomized, controlled trials said,"Ascorbic acid provides effective nephroprotection against CI-AKI and may form a part of effective prophylactic pharmacological regimens"(8).

Vitamin E, is a fat soluble antioxidant found abundantly in sweet potato may be effective in combination with 0.9% saline against CI-AKI in CKD patients(5).
In animal model, alpha tocopherol showed protective effect on renal damage induced CIN,through significant increase of renal SOD, reduction in MDA and an increase of TAC in serum(9).
Furthermore, Dr, Tasanarong A and professors at the Thammasat University said, "Prophylactic oral administration of alpha tocopherol is capable of protecting against CIN in patients with chronic kidney disease undergoing elective coronary procedures"(10).

The effectiveness of Baking Soda, Sweet Potato and Orange Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Contrast-induced nephropathy with little or no adverse effects.

People who are at high risk of Contrast-induced nephropathy due to kidney disease should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary.

(1) Contrast-Induced Nephropathy by Author: Renu Bansal, MD; Chief Editor: Vecihi Batuman, MD, FACP, FASN more(Medscape)
(2) Comparison of short-term infusion regimens of N-acetylcysteine plus intravenous fluids, sodium bicarbonateplus intravenous fluids, and intravenous fluids alone for prevention of contrast-induced nephropathy in the emergency department by Kama A1, Yılmaz S, Yaka E, Dervişoğlu E, Doğan NÖ, Erimşah E, Pekdemir M.(PubMed)
(3) Comparison of combination therapy of high-dose oral N-acetylcysteine and intravenous sodium bicarbonatehydration with individual therapies in the reduction of Contrast-induced Nephropathy during Cardiac Catheterisation and Percutaneous Coronary Intervention (CONTRAST): A multi-centre, randomised, controlled trial by Chong E1, Poh KK2, Lu Q3, Zhang JJ4, Tan N5, Hou XM6, Ong HY7, Azan A8, Chen SL4, Chen JY5, Ali RM8, Fang WY6, Lau TW9, Tan HC10.(PubMed)
(4) Sodium bicarbonate therapy for prevention of contrast-induced nephropathy: a systematic review and meta-analysis by Navaneethan SD1, Singh S, Appasamy S, Wing RE, Sehgal AR.(PubMed)
(5) New strategy of α- and γ-tocopherol to prevent contrast-induced acute kidney injury in chronic kidney disease patients undergoing elective coronary procedures by Tasanarong A1, Vohakiat A, Hutayanon P, Piyayotai D.(PubMed)
(6) Protective effects of anti-oxidant supplementations on contrast induced nephropathy after coronary angiography: an updated and comprehensive meta-analysis and systematic review by Ali-Hassan-Sayegh S, Mirhosseini SJ1, Ghodratipour Z, Sarafan-Chaharsoughi Z, Dehghan AM, Rahimizadeh E, Shahidzadeh A, Lotfaliani MR, Sedaghat-Hamedani F, Kayvanpour E, Sabashnikov A, Popov AF.(PubMed)
(7) N-acetylcysteine and/or ascorbic acid versus placebo to prevent contrast-induced nephropathy in patients undergoing elective cardiac catheterization: The NAPCIN trial; A single-center, prospective, randomized trial by Habib M1, Hillis A, Hammad A.(PubMed)
(8) Does ascorbic acid protect against contrast-induced acute kidney injury in patients undergoing coronary angiography: a systematic review with meta-analysis of randomized, controlled trials by Sadat U1, Usman A, Gillard JH, Boyle JR.(PubMed)
(9) Protective effect of alpha tocopherol on contrast-induced nephropathy in rats by Kongkham S1, Sriwong S, Tasanarong A.(PubMed)
(10) Protection of radiocontrast induced nephropathy by vitamin E (alpha tocopherol): a randomized controlled pilot study by Tasanarong A1, Piyayotai D, Thitiarchakul S.(PubMed)

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