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Thursday, June 30, 2016

The Best Smoothie of Green Tea, Blueberry and Grape for Reduced Early Onset and Treatment of Liver Diseases

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Liver disease
Yield: 2 servings (about 8 ounces each)
1 cup blueberry
1/2 cup grape
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of  Liver disease   has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Liver disease or hepatic disease is defined as a condition of damage of liver or inflammatory causes of diseases to the liver.
Recent reports of study back by renowned institutions, conveyed that green tea(1) may be holding a key for extracting natural ingredient for reduced early onset and treatment of liver diseases.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the Saitama Cancer Center Research Institute,, regular intake of green tea drink is associated to protective effects against liver diseases(1).

In eight-week-old male C57BL/6J mice, fed a normal chow diet or high-fat diet (HFD) for 17 weeks, intake of pu-erh tea extract (PTE) ameliorated hepatic lipid metabolism, inflammation, and insulin resistance functions through by modulating hepatic IL-6/STAT3 signaling, the pro inflammatory pathway(2).
Dr. Yin X and colleagues at joint study lead by the Zhujiang Hospital of Southern Medical University, regardless of the race of the individual concerned where the Asian, American and European, green tea reduced risk of liver diseases, including hepatitis,hepatocellular carcinoma, liver steatosis, chronic liver disease,....(3).

Resveratrol, found abundantly in grape and blueberry,  is a plant-derived polyphenol with a potential as a food source to extend lifespan and healthspan in model organism. According to the University of Kansas Medical Center, the phytochemical exerted liver protective effects in xenobiotic-induced liver injury and other forms of liver injury(4). Also in acetaminophen hepatotoxicity causes of cause of acute liver injury and liver failure, resveratrol protected against Overdose of acetaminophen (APAP) hepatotoxicity through exhibiting antioxidant effects and preventing mitochondrial release of enzyme endonucleases and nuclear DNA damage(5).
Furthermore, the phytochemical may also be potential in reduced risk and treatment of liver fibrosis via the regulation of pro inflammatory, Akt/NF-κB pathways(6).

Pterostilbene, another antioxidant found in bluebrerry, used conjunction with resveratrol (RESV) expressed genotoxic and/or antigenotoxic effects through pro-apoptotic activity in HepG2 cells lines(7). Furthermore, pterostilbene also is potential against acetaminophen-induced hepatotoxicity(8), dimethylnitrosamine-induced liver fibrosis(9), plasma lipoproteins and cholesterol in hypercholesterolemic(10).

The finding of the effectiveness of Green Tea, Grape and Blue Berry may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of  Liver disease.

People who are at increased risk of  Liver disease, due to family history, alcohol drinking,....should drink the juices at least one a day. People with  Liver disease should drink the juice as much as  as they can depending to digestive toleration.
Life style and diet pattern change are recommended.

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References
(1) Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases by Imai K1, Nakachi K.(PubMed)
(2) Pu-erh tea extract ameliorates high-fat diet-induced nonalcoholic steatohepatitis and insulin resistance by modulating hepatic IL-6/STAT3 signaling in mice by Cai X1,2,3, Fang C2,4, Hayashi S2,3, Hao S5, Zhao M6, Tsutsui H2,3, Nishiguchi S7, Sheng J8.(PubMed)
(3) The effect of green tea intake on risk of liver disease: a meta analysis by Yin X1, Yang J2, Li T3, Song L4, Han T5, Yang M1, Liao H1, He J1, Zhong X1.(PubMed)
(4) Critical review of resveratrol in xenobiotic-induced hepatotoxicity by McGill MR1, Du K2, Weemhoff JL2, Jaeschke H2.(PubMed)
(5) Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity by Du K1, McGill MR1, Xie Y1, Bajt ML1, Jaeschke H2.(PubMed)
(6) Resveratrol attenuates the progress of liver fibrosis via the Akt/nuclear factor-κB pathways by Zhang H1, Sun Q1, Xu T1, Hong L1, Fu R1, Wu J1, Ding J1.(PubMed)
(7) In Vitro Safety/Protection Assessment of Resveratrol and Pterostilbene in a Human Hepatoma Cell Line (HepG2) by Lombardi G, Vannini S, Blasi F, Marcotullio MC, Dominici L, Villarini M, Cossignani L, Moretti M(PubMed)
(8) Protective effects of pterostilbene against acetaminophen-induced hepatotoxicity in rats by El-Sayed el-SM1, Mansour AM, Nady ME.(PubMed)
(9) Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats by Lee MF1, Liu ML, Cheng AC, Tsai ML, Ho CT, Liou WS, Pan MH.(PubMed)
(10) Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters by Rimando AM1, Nagmani R, Feller DR, Yokoyama W.(PubMed)

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