Herbal Catnip may have a potential and substantial effect of reducing the risk of pre-malignant cells, caused by slowly changing from normal cells to cancer-like properties in initiated prostate cancer, some scientists suggested.
Catnip is also known as catswort, or catmint, a plant of Nepeta, belongings to the family of Lamiaceae, native to Europe and Asia'
The plant has been used in herbal medicine as an insect repellent and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..
Prostate cancer is a medical condition characterized by irregular cell growth in the issues of the prostate.
At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistic, based on 2012-2014 data, approximately 11.6 percent of men are diagnosed with prostate cancer at some points during their lifetime.
On PC3 and DU145 prostate cell lines, in comparison of the effective of methanol extracts, n-hexan, methylene chloride (CH2Cl2), ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O fractions and the essential oil isolated from the aerial parts of the catnip to examine the cytotoxic and apoptogenic activity, researchers found that application of ethyl acetate extract compared to other extracts, displays a strong inhibited property in decreased prostate cancer cell viability in PC3 cell line, through cell cycle arrest in the sub-G1 area.
The ethyl acetate extract also caused lost some DNA structure in tested cell lines, in a concentration-dependent manner.
Furthermore, through observation of IC 50 values, ethyl acetate (EtOAc) expressed a greater significant activity in estrogen receptor positive PC3 cells which are more sensitive to the cytotoxic effects in comparison with low hormone-receptor presenting DU-145 cells.
Interestingly, ethyl acetate (EtOAc) in inhibited PC3 cancer cell line with the lesser value of IC50 and greater effect than other tested compounds,
The results of these effects were attributed to the activity of PC3 cells which process a property to change its negative androgen receptors profile to positive (PC3AR+)
The study also indicated that more cytotoxic activity of N. cataria found on PC3 cells in comparison with DU145 AR¯ cells might also be associated with the different response of cells to sex hormones.
Additionally, according to the Western blotting analysis administration of ethyl acetate extract after 48 hours securely induced cancer apoptosis through activated caspase 3 cleavage and Poly(ADP-ribose) polymerase (PARP).
Caspase 3 cleavage is an important marker associated with the progression of the cancer cell’s entry point into the apoptotic signaling pathway.
Poly(ADP-ribose) polymerase (PARP) plays an essential role in the execution of the cells apoptosis and is considered an early indicator of apoptosis.
Moreover, researchers also found that the Catnip extract also increased the level of Bax Protein after 48 hours of exposure in initiated cancer cell apoptosis with release of cytochrome c, an early phase of cell degradation and death.
After taking into account of other confounders, Dr. Emami SA, the lead author said, " the semi-polar EtOAc extract of N. cataria induces apoptosis in pc3 cells to compare to DU-145 cells and further analytical assays are suggested to identify the active phytochemicals possess cytotoxic activity".
Taking all together, Catnip and its extract may be considered as a functional food in reduced risk of Prostate cancer through blocking the entry phase of the onset of prostate cancer.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines by Emami SA1, Asili J, Hossein Nia S, Yazdian-Robati R, Sahranavard M, Tayarani-Najaran Z. DOI:http://dx.doi.org/10.7314/APJCP.2016.17.S3.125
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