Sex hormone testosterone plays an essential role on the male reproductive physiology, including the testes, a primary productive organ in the production of spermatozoa and reproductive hormones.
Furthermore, the male steroid hormone also processes a specific function in building bone and muscle mass as well as stimulating sexual desire in both sexes.
In women, testosterone is produced by the ovaries in women in a small amount. The hormone also produced small quantities by the adrenal glands in both sexes.
Truly, overexpression of testosterone may cause reduced production of antioxidants, such as glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) by natural antioxidant enzymes and increased presence of free radical in the body, that can lead to cytotoxicity and weaken function of immune system.
In other words, abnormally high levels of testosterone in the blood can alter the balance the ratio of antioxidants and free radicals in the body, leading to free radicals in the induction of oxidative stress, a primarily causes of chronic ailments.
Some researchers suggested that overproduction of testosterone may associate to increase the risk of prostate cancer, caused by oxidative stress effects in the prostate gland.
On the other hand, underexpression of testosterone may induce symptoms of erectile dysfunction, reduced sperm count and sperm quality, decreased libido or sexual activity, infertility, reduced muscle mass...... and increased body fat.
According to the Catholic University of The Sacred Heart, hypogonadism in men also reduced production of natural antioxidants that also lead to oxidative stress, related to augmented cardiovascular risk(8).
In immune response, low levels of testosterone may increase immune production of white blood cells that protects the body against infection. However, a prolonged period of low levels of testosterone can also lead to long-term overproduction of white blood cells, a leading cause of autoimmune diseases.
Garlic may be the next generation of natural testosterone reducer or inducer. Garlic increases production of the hormone when it is low and inhibits excessive testosterone when it is high.
Garlic (Allium sativum) is a species in the onion genus, belongings to family Amaryllidaceae, native to central Asia.
The herb or food has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure, cholesterol, natural antibiotic, etc.
Dr. Prasad S lead research at the Industrial Toxicology Research Centre, diallyl sulfide (DAS), a constituent of garlic, exerted antioxidant activities against testosterone-induced oxidative stress in male Swiss albino mice, by significantly restored the testosterone-induced antioxidant enzymes and decreased lipid peroxidation.
The effects of garlic supplementation on protein metabolism also suggested that dietary supplementation with 0.8 g/100 g garlic alters hormones associated with protein anabolism by increasing testicular testosterone and decreasing plasma corticosterone in rats fed a high protein diet.
In the concerns of conventional medicine driamycin (ADR), a potent cytotoxic drug that causes many adverse effects on different body organs, researchers at the Faculty of Medicine, Zagazig University conducted an experience to evaluate the effect of aged garlic extract (AGE) when it is used combination with driamycin (ADR).
At the end of the study, the researcher found that aged garlic extract (AGE), a garlic preparation, AGE can be used as an adjuvant therapy to resume male infertility and weak spermatogenesis induced by cytotoxic drugs or other environmental toxins through its cytoprotective and antioxidant properties.
In fact, like all natural phytochemicals, garlic is both testosterone booster and testosterone reducer, depending on the levels of testosterone in the body and amount of garlic intake.
However, the use of garlic extracts and supplements should be taken with care, as overdoses may induce liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective role of garlic oil against oxidative damage induced by furan exposure from weaning through adulthood in adult rat testis by El-Akabawy G1, El-Sherif NM2.(PubMed)
(2) Chronic crude garlic-feeding modified adult male rat testicular markers: mechanisms of action by Hammami I1, Amara S, Benahmed M, El May MV, Mauduit C.(PubMed)
(3) The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding by Hammami I1, Nahdi A, Mauduit C, Benahmed M, Amri M, Ben Amar A, Zekri S, El May A, El May MV.(PubMed)
(4) Modulatory effects of diallyl sulfide against testosterone- induced oxidative stress in Swiss albino mice by Prasad S1, Kalra N, Shukla Y.(PubMed)
(5) Testosterone and oxidative stress: the oxidation handicap hypothesis by Carlos Alonso-Alvarez,1,* Sophie Bertrand,1 Bruno Faivre,2 Olivier Chastel,3and Gabriele Sorci1,2(The Royal Society Publicizing)
(6) https://www.stronghealthtips.com/garlic
(7) Effects of testosterone on antioxidant systems in male secondary hypogonadism by Mancini A1, Leone E, Festa R, Grande G, Silvestrini A, de Marinis L, Pontecorvi A, Maira G, Littarru GP, Meucci E(PubMed)
(8) The impact of aged garlic extract on adriamycin-induced testicular changes in adult male Wistar rats by Nasr AY(PubMed)
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