Today, many whole herb ingredients worked together in herbal plants were proven effective in reduced risk and treatment of various diseases with little or no side effects by many respectable scientists through intensive research and studies. However, intake of a synthetic version of single-ingredient isolated from such plants may produce opposite outcomes.
A recent study suggested that Chaste Tree Berry may be used to protect the internal structures of the eyes against selenite-induced cataractogenesis.
Selenite cataract is a rapidly-induced, convenient model for the study of age-related (senile) cataract.
Selenite, named from the Ancient Greek word for the Moon. is a crystal-like substance of mineral gypsum, composed of calcium sulfate dihydrate. It is one of Chinese herb used for the treatment of heat and fire syndromes.
Long-term contact with the crystal may cause side effects of a headache, unstable emotional expression,..... and dizziness.
Cataractogenesis is a process of cataract formation.
Cataract, one of common vision loss in people over age 40 and a leading cause of blindness, is a condition of blurry vision caused by clouding of the lens in one or both eye(s).
According to a statistic provided by Laser Eye Surgery Hub, In England, 30% of people 65 years or older have a visually impairing cataract in one or both eye(s). 10% of people 65 or over had already had cataract surgery. 95% of cataracts are age-related, usually after age 40.
There are many causes of cataract, some researchers suggested that aging and injury that cause the changes the tissue made up the eye's lens, past eye surgery or medical conditions such as diabetes are the common causes of the disease.
However, some inherited genetic disorders such as chromosome abnormalities, Lowe syndrome,,,,
and neurofibromatosis type 2, also are associated to increase the risk of cataracts too.
Believe or not, cataracts can also be caused by other eye conditions.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region.
The herb has been used in herbal medicine for thousands of year as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
According to the University of Kerala, flavonoids found in the chaste tree berry exerted cataract protective effect in prevented damage of lenticular membrane and abnormal fiber structure in a patient with cataract viewed through electron microscopy.
Furthermore, the study also found that chaste tree berry expresses a significant improvement of chaperone property of α-crystalline and soluble protein levels in two dimensional-polyacrylamide gel electrophoresis (2D-PAGE) and immunoblot analysis.
α-crystallin, a structural lens protein plays an important role in protecting the eyes against the formation of eye diseases, including cataract.
Dr. Rooban BN, the lead author said, " FVN modulated selenite-induced cataractogenesis in rat pups by preventing loss of chaperone property, various changes in lens proteins, and lens structure, further strengthening its protective role".
Some researchers suggested that the efficacy of chaste tree berry in reduced risk and treatment of cataract may be a result of phytochemical antioxidants activity in scavenge free radicals that cause oxidative stress, loss of calcium homeostasis, calpain activation and protein insolubilization.
More importantly, in a study of eight-day-old Sprague-Dawley rat pups divided into four groups: Control (GI), Sodium selenite-induced (G II), Sodium selenite+quercetin treated (G III), Sodium selenite+flavonoids from Vitex negundo (FVN) (G IV), group fed with sodium selenite+flavonoids showed normal levels of expression of lens of water-soluble proteins compared to other groups.
In fact, pups treated with FVN was found to exhibit the antioxidant effects in modulating biochemical parameters against selenite-induced cataract, the University of Kerala insisted.
In support to the above differentiation, the Sprague-Dawley rat pups of 8 days old divided into control (G I), selenite-induced (G II), and selenite + V. negundo treated (G III) with cataract induced by the single subcutaneous injection of sodium selenite (4 mg/kg body weight) on the tenth day and V. negundo (2.5 mg/Kg body weight) administered intraperitoneally from eighth to 15th day study, researchers showed that group III exert significantly reduced activities of superoxide dismutase, catalase, lower level of reactive oxygen species, Ca(2+), and thiobarbituric acid reactive substance.
Taking together, Chaste tree berry may process of therapeutic potential used for prevention of changes of internal eye structures that stimulated the onset of cataract and treatment of cataract with little adverse effects.
However, additional large sample size and multicenter clinical trials with human consumption during the course of the disease are necessary to reconfirm chaste tree berry anti cataract possibility.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Analysis on the alterations of lens proteins by Vitex negundo in selenite cataract models by Rooban BN1, Sasikala V, Sahasranamam V, Abraham A.(PubMed)
(2) Vitex negundo attenuates calpain activation and cataractogenesis in selenite models by Rooban BN1, Lija Y, Biju PG, Sasikala V, Sahasranamam V, Abraham A.(PubMed)
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