Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen" by Ide H, Tokiwa S, Sakamaki K, Nishio K, Isotani S, Muto S, Hama T, Masuda H, Horie S., posted in US National Library of Medicine National Institutes of Health, researchers found that the production of prostate-specific antigen(PSA) were markedly decreased by the combined treatment of isoflavones and curcumin in prostate cancer cell line, LNCaP. The expression of the androgen receptor was also suppressed by the treatment. In clinical trials, PSA levels decreased in the patients group with PSA >or= 10 treated with supplement containing isoflavones and curcumin (P = 0.01) and concluded that isoflavones and curcumin could modulate serum PSA levels. Curcumin presumably synergizes with isoflavones to suppress PSA production in prostate cells through the anti-androgen effects.