Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "[Effects of soy isoflavones and major active component genistein on the expression of ovarian estrogen receptor-α in rats].[Article in Chinese]" by Zhang YH, Pang HY, Xiao XH, Wen HX, Ni J., posted in US National Library of Medicine National Institutes of Health, researchers found that Soy isoflavones can up-regulate the expressions of ER-α mRNA and protein in senile rat ovaries. As a major active component of soy isoflavones, genistein can regulate the expressions ER-α mRNA in granulosa cells of rat ovaries. Such an effect is concentration-dependent. And 1-10 µmol/L genistein may up-regulate the expression of ER-α mRNA.