In the investigation of "Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries" by Jackman KA, Woodman OL, Chrissobolis S, Sobey CG., posted in US National Library of Medicine National Institutes of Health, found that Equol possesses substantial vasodilator and weak antioxidant activity in cerebral arteries, with similar activity to daidzein, whereas in hypertension the vasorelaxant response to equol, but not daidzein, is preserved. However, daidzein possesses comparable direct vascular effects with equol, without the need for intestinal conversion to equol. Nevertheless, equol may represent a more useful therapeutic agent during cerebral vascular disease.
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