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Thursday, February 16, 2012

Soy and Neuroprotective effects

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health


In the study of "Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease" by Liu LX, Chen WF, Xie JX, Wong MS., posted in US National Library of Medicine National Institutes of Health, found that MPTP significantly decreased the levels of dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum, which could be restored by genistein or estrogen pretreatment. MPTP-challenge with genistein or estrogen pretreatment demonstrated reduced neurotoxicity, with tyrosine hydroxylase-immunoreactive (TH-IR) neurons in the substantia nigra pars compacta (SNpc) affected to a significantly lesser extent as compared to the MPTP treated control.

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