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Sunday, February 19, 2012

Soy isoflavonesand cardioprotection to offspring

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the study of "Dietary isoflavones during pregnancy and lactation provide cardioprotection to offspring rats in adulthood" by Souzeau E, Bélanger S, Picard S, Deschepper CF., posted in US National Library of Medicine National Institutes of Health, researchers found that the soy-based diet had no such effects when given to rats after 6 wk of age, and its effects were replicated when supplementing the maternal casein-based diet with the isoflavones daidzein and genistein (the most abundant phytoestrogens in soy-based diets). In contrast to rats whose mothers had been fed with a soy-based diet, the hearts of adult rats raised with a casein-based diet only featured dilated eccentric hypertrophy and progressed toward congestive heart failure when further challenged. Thus the presence of isoflavones in the maternal diet provides cardioprotection to the hearts of their offspring during adulthood.

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