Posted by Chantel M. Contributed by US National
Library of Medicine National Institutes of Health
In the study to examined the effect of isoflavone-enriched milk on bone loss in ovariectomized (OVX) rats. Thirty 6-week-old Sprague-Dawley female rats were divided into two groups: sham-operated and OVX, posted in PubMed, indicated a significant increase was found in bone density of femur and trabecular
bone area in the OVX+Iso+Vit+Ca group, which almost reached that of the
sham-operated group, whereas no difference was found among the OVX and
OVX+Iso groups. The histological areas of the proximal tibia sections
showed highly filled trabecular bone in both isoflavone-enriched groups
(OVX+Iso and OVX+Iso+Vit+Ca). The present study indicated that
isoflavone-enriched milk may have a partial preventive effect on
ovariectomy-induced bone loss; however, vitamins D and K and Ca enrichment with isoflavone may enhance effectiveness for increasing bone mass in OVX rats.
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