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Saturday, August 4, 2012

Soy tripeptide VPY and Intestinal inflammation

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the examination of the transport of soy-derived di- and tripeptides across Caco-2 intestinal epithelial cells, and the anti-inflammatory effects of the transported peptide VPY (present at residues 153 to 155 of the A5A4B3 subunit of 11S globulin in soybean protein.)  in vitro in Caco-2 and THP-1 macrophages, and in vivo in a mouse model of DSS-induced colitis, posted in PubMed,  showed that VPY is a novel PepT1 substrate that can inhibit the production of pro-inflammatory mediators in vitro in intestinal epithelial and immune cells, and reduce the severity of colitis in mice by down-regulating the expression of pro-inflammatory cytokines in the colon, suggesting that VPY may be promising for the treatment of IBD.

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