Isoflavones and cognitive function in older women

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health


In the study to study examines the effects of a dietary supplement of isoflavones on cognitive function in postmenopausal women, posted in PubMed, researchers showed that at baseline, all women were cognitively intact; there were no significant differences by treatment assignment in age, education, depressed mood, or cognitive function (all P values > 0.10). Compliance was 98% and 97%, respectively, in the placebo and treatment groups; all women took at least 85% of their pills. The women in the treatment group did consistently better, both as compared with their own baseline scores and as compared with the placebo group responses at 6 months. Comparisons of percentage change in cognitive function between baseline and follow-up showed greater improvement in category fluency for women on active treatment as compared with the case of those on placebo (P = 0.02) and showed (nonsignificantly) greater improvement on the two other tests of verbal memory and Trails B and concluded that isoflavone supplementation has a favorable effect on cognitive function, particularly verbal memory, in postmenopausal women.

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