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Sunday, December 27, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: TCM Herbal Medicine for Kidney Yang deficiency - Gou Qi Zi

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
                               
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).




PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

Kidney yang deficiency

Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yang deficiency may also experience yang vacuity induced cold expressive syndrome, including
lumbago, cold limbs, fatigue, cold aversion, feverish sensation in chest, palms and soles(1573),
difficulty in urination, enuresis, incontinence, declining libido and edema(1574) as a result of kidneys no longer perform their function in store fluid to moister and warm the body for healthy function in the body's organs and tissues, inducing adrenal insufficient chronic lower back pain(1575)(1580), depression(1575), hypothyroidism(1579)(1575), nephritis(1578)(1575), ...(1575), leading to failure in transform damp heat expression, promoted accentuation of inflammatory development of phlegm(1583).
Kidney yang deficiency has shown to alter carbohydrate and lipid metabolisms (free fatty acids, 1-monolinoleoylglycerol, and cholesterol), gut microbiota metabolism (indole-3-propionic acid), indued anovulatory infertility( 1581) and hypertension(1582) of which related to symptoms of PCOs(1576)(1577).



Herbal medicine for kidney yang deficiency

4. Lycium chinense(Qi Zi)(1759)
Gou Qi Zi or Qi Zi is also known as wolfberry fruit. The sweet and neutral herb has been used in TCM as anti cancer(1748)(1749)(1750), antiviral(1751), and antiinflammatory(1751) agent and to treat weakness(1768) mental acuity(1768), shortness of breath(1768), memory and neurogenesis impairments(1752), relieve pain(1753) improve vision(1754)(1755), anemia(1754), diabetes(1756), promote antiaging(1757), enhance immune system(1751), heart function(1751), lower blood lipids(1751), modulate estrogen receptors(1750) etc., as it nourishes and tonifies liver and kidneys by enhancing the functions of liver, lung and kidney channels(1758).

Chemical constituents(1758)
1. Betaine
2. β-sitosterol
3. Linoleic acid
4. Physalien
5. Cryptoxanthin
6. Atropine
7. Hyoscyamine
8. Scopoletin
9. Amino acids
10. Physalein
11. Zeaxanthin
12. Dipalmitate
13. Carotene
14. Etc.


Epidemiologically, wolfberry also processed anti oxidant(1763)(1762) and anti inflammatory(1765)(1764), anti insulin resistance(1760)(1761), anti depression(1767), sleep disorder(1768), anti stress(1768), anti mental deficits(1768) and anti metabolic syndrome(1766), through its enhanced carbohydrate(1770), lipid(1766) and other metabolic(1766) mechanisms, including fasting glucose(1770), hypertensive(1771)(1772), anti hyperglycaemic(1769)(1770)(1774), anti hyperlipidemic(1773)(1774), weight gain(1770), obesity, ,,, of which induced protective effects against the development of diabetes(1775)(1776) and cardiovascular disease(1777)(1751)(1778).

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References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) by Liqin Zhao


(1748) Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer by Luo Q1, Li Z, Yan J, Zhu F, Xu RJ, Cai YZ.(PubMed)
(1749) [Observation of the effects of LAK/IL-2 therapy combining with Lycium barbarum polysaccharides in the treatment of 75 cancer patients]. [Article in Chinese] by Cao GW1, Yang WG, Du P.(PubMed)
(1750) Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism by Li G1, Sepkovic DW, Bradlow HL, Telang NT, Wong GY.(PubMed)
(1751) An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides by Cheng J1, Zhou ZW2, Sheng HP3, He LJ4, Fan XW5, He ZX6, Sun T7, Zhang X8, Zhao RJ9, Gu L10, Cao C2, Zhou SF11.(PubMed)
(1752) Lycium barbarum polysaccharides prevent memory and neurogenesis impairments in scopolamine-treated rats by Chen W1, Cheng X2, Chen J3, Yi X2, Nie D4, Sun X5, Qin J2, Tian M2, Jin G2, Zhang X2.(PubMed)
(1753) [Effects of lycium barbarum polysaccharide on formation of traumatic neuroma and pain after transection of sciatic nerve in rats]. [Article in Chinese] by Fan H1, Deng C, Fu J, Ding L, Yin G, Ma Y.(PubMed)
(1754) Lycium (Lycium barbarum) by Cassileth B1.(PubMed)
(1755) Goji berry effects on macular characteristics and plasma antioxidant levels by Bucheli P1, Vidal K, Shen L, Gu Z, Zhang C, Miller LE, Wang J.(PubMed)
(1756) Anti-diabetic effects of the ethanol extract of a functional formula diet in mice fed with a fructose/fat-rich combination diet by Cheng Q1, Zhang X, Wang O, Liu J, Cai S, Wang R, Zhou F, Ji B.(PubMed)
(1757) Comparative evaluation of the antioxidant effects of the natural vitamin C analog 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from Goji berry fruit by Zhang Z1, Liu X, Zhang X, Liu J, Hao Y, Yang X, Wang Y.(PubMed)
(1758) Qi Zi(Complementary and Alternative Healing University)
(1759) Chinese Herbs – Gou Qi Zi or Qi Zi (Fructus Lycii) by Kyle J. Norton
(1760) A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cellsby Liu J1, Zhang H, Ji B, Cai S, Wang R, Zhou F, Yang J, Liu H.(PubMed)
(1761) Dietary Lycium barbarum polysaccharide induces Nrf2/ARE pathway and ameliorates insulin resistance induced by high-fat via activation of PI3K/AKT signaling by Yang Y1, Li W2, Li Y2, Wang Q2, Gao L3, Zhao J4.(PubMed)
(1762) Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults by Amagase H1, Sun B, Borek C.(PubMed)
(1763) Effect of drying methods on physicochemical properties and antioxidant activities of wolfberry (Lycium barbarum) polysaccharide by Zhao Q1, Dong B2, Chen J2, Zhao B3, Wang X1, Wang L1, Zha S4, Wang Y1, Zhang J5, Wang Y5.(PubMed)
(1764) Anti-inflammatory effect of Lycii radicis in LPS-stimulated RAW 264.7 macrophages by Song MY1, Jung HW, Kang SY, Kim KH, Park YK.(PubMed)
(1765) Anti-inflammatory effect of Lycium Fruit water extract in lipopolysaccharide-stimulated RAW 264.7 macrophage cells by Oh YC1, Cho WK, Im GY, Jeong YH, Hwang YH, Liang C, Ma JY.(PubMed)
(1766) Metabolic Signatures of Kidney Yang Deficiency Syndrome and Protective Effects of Two Herbal Extracts in Rats Using GC/TOF by MS. Zhao L1, Wu H, Qiu M, Sun W, Wei R, Zheng X, Yang Y, Xin X, Zou H, Chen T, Liu J, Lu L, Su J, Ma C, Zhao A, Jia W.(PubMed)
(1767) Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats(1) by Zhang E1, Yau SY, Lau BW, Ma H, Lee TM, Chang RC, So KF.(PubMed)
(1768) A meta-analysis of clinical improvements of general well-being by a standardized Lycium barbarum by Paul Hsu CH1, Nance DM, Amagase H.(PubMed)
(1769) Evaluation of hypoglycemic activity of the polysaccharides extracted from Lycium barbarum by Jing L1, Cui G, Feng Q, Xiao Y.(PubMed)
(1770) Hypoglycemic effects and mechanisms of action of Cortex Lycii Radicis on alloxan-induced diabetic mice by Gao D1, Li Q, Liu Z, Li Y, Liu Z, Fan Y, Li K, Han Z, Li J.(PubMed)
(1771) Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum polysaccharides in a mouse model of acute ocular hypertension by Mi XS1, Feng Q, Lo AC, Chang RC, Lin B, Chung SK, So KF.(PubMed)
(1772) Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity by Potterat O1.(PubMed)
(1773) Effects of Lycium barbarum polysaccharides on oxidative stress in hyperlipidemic mice following chronic composite psychological stress intervention by Zhu X1, Hu S1, Zhu L1, Ding J1, Zhou Y1, Li G1.(PubMed)
(1774) Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum by Luo Q1, Cai Y, Yan J, Sun M, Corke H..(PubMed)
(1775) Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes by Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, Lu H, Guo F, Han C, Sun G1.(PubMed)
(1776) Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L. by Zhu J1, Liu W, Yu J, Zou S, Wang J, Yao W, Gao X.(PubMed)
(1777) Lycium barbarum polysaccharides reduce intestinal ischemia/reperfusion injuries in rats by Yang X1, Bai H, Cai W, Li J, Zhou Q, Wang Y, Han J, Zhu X, Dong M, Hu D.(PubMed)
(1778) [Effect of Lycium ruthenicum anthocyanins on atherosclerosis in mice]. [Article in Chinese] by Lin L1, Li J, Lv H, Ma Y, Qian Y.(PubMed)

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