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Tuesday, December 15, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: The Nutritional supplement Magnesium, according to Traditional Chinese Medicine

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                     In Traditional Chinese Perspective
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.

Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).

Nutritional Supplements according to Traditional Chinese Medicine

Modern traditional Chinese medicine doctors may also recommend the list of nutritional supplements for management and treatment of PCOs, depending to differentiation.
2. Magnesium
Magnesium, a micro nutrient and trace mineral found abundantly in spices, nuts, cereals, cocoa and vegetables such as spinach. Today approximately 5% - 15% of world population are found to have low level of serum ofMg(1470), probably due to reduced dietary magnesium intake associated to food refining and modern fertilizers that contain no magnesium(1471). In US, 68% of population are found to have dietary intake of Mg below recommend levels(1472).
Deficiency of Magnesium may cause learning and memory deficiency(1473), reduced metabolisms(1474)(1475)(1476), hormone imbalance(1476), altered the gut microbiota(1477) in the digestive system and anxiety(1477)(1478), sleep disorders(1479)(1480), coronary artery vasospasm(1481),arrhythmias(1481)(1490), ischemic damage(1481) and cardiac failure(1481), etc....

Epidemiological studies suggested that magnesium also exhibits anti cancer(1500)(1501)(1502) anti metabolic syndrome(1482(1485)(1484) effects such as hypertension(1483)(1487), obesity(1486)(1487), elevated fasting plasma glucose(1488)(1489), high serum triglycerides(1488)(1491), and low high-density lipoprotein (HDL) levels(1488)(1490), etc,... and reduces risk insulin resistance(1482)(1484)(1490), cardiovascular disease(1482) and diabetes(1483)(1484), migraine headache(1492)(1493)(1495), premenstrual syndrome(1494)(1495), depression(1478)(1496), stress(1497)(1498), etc,... of which may be helpful for management and treatment of women with PCOs.

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(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(1470) Contemporary view of the clinical relevance of magnesium homeostasis by John Ayuk and Neil JL Gittoes(Biochemistry)
(1471) Magnesium by Wester PO.(PubMed)
(1472) Magnesium(Wikipedia)
(1473) Magnesium protects cognitive functions and synaptic plasticity in streptozotocin-induced sporadic Alzheimer's model by Xu ZP1, Li L1, Bao J1, Wang ZH1, Zeng J1, Liu EJ1, Li XG1, Huang RX1, Gao D1, Li MZ1, Zhang Y2, Liu GP1, Wang JZ1.(PubMed)
(1474) Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients by Bourre JM1.(PubMed)
(1475) The paradox of the contrasting roles of chronic magnesium deficiencyin metabolic disorders and field cancerization by Rubin H1.(PubMed)
(1476) Hormonal imbalance and disturbances in carbohydrate metabolismassociated with chronic feeding of high sucrose low magnesium diet in weanling male wistar rats by Garg M1, Mehra P, Bansal DD.(PubMed)
(1477) Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice by Pyndt Jørgensen B1, Winther G2, Kihl P1, Nielsen DS3, Wegener G2, Hansen AK1, Sørensen DB1.(PubMed)
(1478) [Magnesium deficiency and anxiety-depressive syndrome in elderly patients with chronic heart failure].[Article in Russian] by Uteva AG, Pimenov LT.(PubMed)
(1479) Magnesium supplementation improves indicators of low magnesiumstatus and inflammatory stress in adults older than 51 years with poor qualitysleep by Nielsen FH1, Johnson LK, Zeng H.(PubMed)
(1480) Magnesium involvement in sleep: genetic and nutritional models by Chollet D1, Franken P, Raffin Y, Henrotte JG, Widmer J, Malafosse A, Tafti M.(PubMed)
(1481) Protective role of magnesium in cardiovascular diseases: a review by Chakraborti S1, Chakraborti T, Mandal M, Mandal A, Das S, Ghosh S.(PubMed)
(1482) Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X by Barbagallo M1, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, Pineo A, Busardo' A, Paolisso G.(PubMed)
(1483) Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium by Paolisso G1, Barbagallo M.(PubMed)
(1484) Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance by Barbagallo M1, Dominguez LJ.(PubMed)
(1485) Magnesium deficiency and metabolic syndrome: stress and inflammation may reflect calcium activation by Rayssiguier Y1, Libako P, Nowacki W, Rock E.(PubMed)
(1486) Magnesium, inflammation, and obesity in chronic disease by Nielsen FH1.(PubMed)
(1487) [Obesity and hypertension: the role of magnesium]. [Article in Italian] by Corica F1, Allegra A, Buemi M, Ientile R, Corsonello A, Bonanzinga S, Macaione S, Ceruso D.(PubMed)
(1488) Serum magnesium concentrations in polycystic ovary syndrome and its association with insulin resistance by Sharifi F1, Mazloomi S, Hajihosseini R, Mazloomzadeh S.(PubMed)
(1489) Fasting plasma magnesium concentrations and glucose disposal in diabetes by Yajnik CS, Smith RF, Hockaday TD, Ward NI.(PubMed)
(1490) Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women by Nielsen FH1, Milne DB, Klevay LM, Gallagher S, Johnson L.(PubMed)
(1491) The absorbability by rats of various triglycerides of stearic and oleic acid and the effect of dietary calcium and magnesium by Mattson FH, Nolen GA, Webb MR.(PubMed)
(1492) Serum and salivary magnesium levels in migraine and tension-type headache. Results in a group of adult patients by Sarchielli P1, Coata G, Firenze C, Morucci P, Abbritti G, Gallai V.(PubMed)
(1493) Serum and salivary magnesium levels in migraine. Results in a group of juvenile patients by Gallai V1, Sarchielli P, Coata G, Firenze C, Morucci P, Abbritti G.(PubMed)
(1494) Interrelationship of magnesium and estrogen in cardiovascular and bone disorders, eclampsia, migraine and premenstrual syndrome by Seelig MS1.(PubMed)
(1495) Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome by Fathizadeh N1, Ebrahimi E, Valiani M, Tavakoli N, Yar MH.(PubMed)
(1496) Magnesium in depression by Serefko A1, Szopa A, Wlaź P, Nowak G, Radziwoń-Zaleska M, Skalski M, Poleszak E.(PubMed)
(1497) Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep by Nielsen FH1, Johnson LK, Zeng H.(PubMed)
(1498) Magnesium, stress and neuropsychiatric disorders by Galland L1.(PubMed)
(1499) Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review) by Seelig MS1.(PubMed)
(1500) Dietary magnesium intake and risk of cancer: a meta-analysis of epidemiologic studies by Ko HJ1, Youn CH, Kim HM, Cho YJ, Lee GH, Lee WK.(PubMed)
(1501) Magnesium and cancer: a dangerous liason by Castiglioni S1, Maier JA.(PubMed)
(1502) Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality by Leone N1, Courbon D, Ducimetiere P, Zureik M.(PubMed)

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