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Monday, December 7, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: The Dietary Suggestion according to TCM(Part II)

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective

While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.
Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).


                             The Dietary Suggestion according to TCM

6. Eat organic meats only
Grass-fed and grain-fed cattle have shown to significantly improve the fatty acid (FA) composition(1273)(1274) and antioxidant content of beef(1273).According to Norwegian University of Life Sciences, Pig feeds rich in rapeseed products contains high concentration of EPA, DPA, and DHA of which have shown to benefit to over health for the consumer(1272).

7. Intake of berries has shown to contribute to beneficial metabolic effects in preventing obesity(1275) and related disorders(1275)(1278)(1279), such as ameliorating total cholesterol and LDL-cholesterol(1276), hyperglycemia(1277) and insulin sensitivity(1277), lowering fasting insulin level(1275),......

8. Intake cinnamon daily can improve insulin resistance and PCOs related metabolic syndrome
(See the Insulin resistance improvement and/or anti metabolic syndrome herb: Cinnamon for more information)
[Cinnamon is a spice derived from the inner bark of tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belongings to the familyLauraceae used in herbal and traditional medicine as anti-microbial agent(1087) and to improve reproductive organs(1088), prevent flatulence(1089) and menstrual cramping(1087), treat gastrointestinal complaints(1089), diarrhea(1087), bad breath(1090), headache(1087), etc.(1086)(1087).

1. Cinnamic aldehyde
2.Cinnamyl acetate
3. Eugenol
4. Aldehyde
5. Pinene
6. Coumarins
7. Cinnzeylanol
8. Cinnzeylanine
9. Safrol
10. Methylhydroxy chalcone polymer (MHCP)

Epidemiological studies suggested that cinnamon consist a significant anti insulin resistance(1091)(1092)(1094) and anti metabolic syndrome(1093)(1094)(1095)(1096)(1097) properties, such as lowering total cholesterol(1093), low-density lipoprotein cholesterol(1093) and improving high-density lipoprotein cholesterol(1093), may be due to its antihyperglycaemic (1091)(1093) and potential to reduce postprandial blood glucose levels(1091)(1092), liver fat(1098) and and improved glucose homeostasis(1098) properties, by regulating the mechanisms of-medicated glucose and lipid metabolism(1099), such as decreased the mRNA expression of inflammatory cytokine(TNF-alpha) in adipose tissue(1100) and upregulated mRNA expression of insulin-regulated membrane trafficking(1100) and whole body glucose homeostasi(GLUT-4) in skeletal muscle(1100)].

9. Adding bitter Melon and fenugreek into your diet
Epidemiological studies suggested that bitter melon displays a modest hypoglycemic effect(1280)(1281)(1283)and anti related complications in metabolic syndrome(1281)(1282).
Fenugreek not only showed to promote sexual arousal and desire in women, probly through its regulationj of total and free testosterone and other hormone(1284) but also exhibited hypoglycemic and hypocholesterolemic effects in in a dose-dependent manner(1285)

10. Insure adequate fiber intake through eating a lots of fresh vegetables and whole grains.
High-fiber diets, especially of the soluble variety, and soluble fiber supplements has been recommended by several national diabetes associations management of the plasma glucose concentration in individuals with diabetes(1286)(1288) as it offers some improvement in carbohydrate metabolism(1287).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(1247b) Polycystic Ovary Syndrome - a TCM Perspective by Donna Dupre, L.Ac.
(1272) Pig feeds rich in rapeseed products and organic selenium increased omega-3 fatty acids and selenium in pork meat and backfat by Gjerlaug-Enger E1, Haug A2, Gaarder M3, Ljøkjel K4, Stenseth RS5, Sigfridson K6, Egelandsdal B7, Saarem K3, Berg P3.(PubMed)
(1273) A review of fatty acid profiles and antioxidant content in grass-fed andgrain-fed beef by Daley CA1, Abbott A, Doyle PS, Nader GA, Larson S.(PubMed)
(1274) Effect of feeding systems on omega-3 fatty acids, conjugated linoleic acid and trans fatty acids in Australian beef cuts: potential impact on human health by Ponnampalam EN1, Mann NJ, Sinclair AJ.(PubMed)
(1275) Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice by Heyman L1, Axling U1, Blanco N2, Sterner O2, Holm C1, Berger K1.(PubMed)
(1276) Polyphenol-rich bilberry ameliorates total cholesterol and LDL-cholesterol when implemented in the diet of Zucker diabetic fatty rats. Brader L1, Overgaard A1, Christensen LP2, Jeppesen PB1, Hermansen K1.(PubMed)
(1277) Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice by Takikawa M1, Inoue S, Horio F, Tsuda T.(PubMed)
(1278) Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome by Puupponen-Pimiä R1, Seppänen-Laakso T, Kankainen M, Maukonen J, Törrönen R, Kolehmainen M, Leppänen T, Moilanen E, Nohynek L, Aura AM, Poutanen K, Tómas-Barberán FA, Espín JC, Oksman-Caldentey KM.(PubMed)
(1279) Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women by Lehtonen HM1, Suomela JP, Tahvonen R, Yang B, Venojärvi M, Viikari J, Kallio H.(PubMed)
(1280) The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: a systematic review and meta-analysis by Yin RV1, Lee NC1, Hirpara H1, Phung OJ1.(PubMed)
(1281) Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients by Fuangchan A1, Sonthisombat P, Seubnukarn T, Chanouan R, Chotchaisuwat P, Sirigulsatien V, Ingkaninan K, Plianbangchang P, Haines ST.(PubMed)
(1282) Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome by Alam MA1, Uddin R2, Subhan N3, Rahman MM1, Jain P1, Reza HM1.(PubMed)
(1283) Protective effect of Momordica charantia fruit extract on hyperglycaemia-induced cardiac fibrosis by Abas R1, Othman F2, Thent ZC2.(PubMed)(1284) Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study by Rao A1, Steels E, Beccaria G, Inder WJ, Vitetta L., (PubMed)
(1285) Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats by Xue WL1, Li XS, Zhang J, Liu YH, Wang ZL, Zhang RJ.(PubMed)
(1286) Dietary fiber in management of diabetes by Vinik AI1, Jenkins DJ.(PubMed)
(1287) Dietary fiber in the management of diabetes by Nuttall FQ1.(PubMed)
(1288) Role of guar and dietary fibre in the management of diabetes mellitus by Cohen M, Leong VW, Salmon E, Martin FI.(PubMed)

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