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Saturday, December 5, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: The Dietary Suggestion according to TCM(Part I)

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

The Dietary Suggestion according to TCM
1. Eat foods low on the Glycemic Index (GI) such as vegetables and whole grains to improve insulin sensitivity(1250), quality of life(1253)and avoid some long-term health risks of endometrial cancer(1252) as many women with PCOS are not achieving dietary intakes and levels of physical activity(1251)

2. Women with PCOS should completely avoid refined carbohydrates as it showed to elevate the risk of type 2 diabetes(1254) induced collection of metabolic defects including peripheral insulin resistance(1255), elevated hepatic glucose output, and impaired pancreatic insulin secretion(1254), immune-mediated diseases(1256), such as reduced control of infection, increased rates of cancer, and increased risk for allergic and auto-inflammatory disease(1256) and inflammation(1255).

3. Keep blood sugar stable by eating regularly with small meal(1258), including good fat, such as monounsaturated and polyunsaturated fatty acids(1259) and protein(1261). According to Diabetes Center, Eulji Hospital, in the differentiation of a meal plan using rice bowls of varying sizes, showed that small rice bowl-based meal plan was effective at reducing dietary energy intake (EI), body weight (BW), and blood glucose levels in comparison to regular rice bowl-based meal plan(1257).
Indeed, high monounsaturated fat hypocaloric diet) or high polyunsaturated fat hypocaloric diet has shown to mprove total cholesterol, LDL cholesterol, triglyceride, glucose, insulin and homeostasis model assessment for insulin resistance(HOMA-R) levels(1260).

4. Eating vegetables daily as including vegetables in rich in fruits,vegetables, whole grains, and low-fat dairy products and low in saturated fats have shown to improve insulin resistance, serum hs-CRP levels, and abdominal fat accumulation(1262). Leafy greens, such as kale, broccoli, collard greens, bok choy, cabbage, rapini, etc.. process the ability in modulation liver fatty acid composition(1263) of which promotesglucose(1264). hormone(1265) regulation and lipids(1264) homeostasis ofmetabolic dysfunction(1264) probably through the effects of its phyotchemical indole-3 carbinol(1266)(1267)(1268). Intake of legumes such as black beans, adzuki beans, mung beans, black-eyed peas etc., also contribute to beneficial effects of on metabolic features, such as insulin resistance(1269), glycated hemoglobin, triglycerides, and total and HDL cholestero(1270). According to Complementary and Alternative Healing University, adzuki bean displays a diuretic property, can beneficiary for draining ‘dampness’ from the body.(1271).
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(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(1247b) Polycystic Ovary Syndrome - a TCM Perspective by Donna Dupre, L.Ac.
(1249) PCOS – A Chinese Medicine Diet and Lifestyle Approach by Angela Warburton
(1250) An isocaloric low glycemic index diet improves insulin sensitivity in women with polycystic ovary syndrome by Barr S, Reeves S, Sharp K, Jeanes YM.(PubMed)
(1251) Habitual dietary intake, eating pattern and physical activity of women with polycystic ovary syndrome by Barr S1, Hart K, Reeves S, Sharp K, Jeanes YM.(PubMed)
(1252) Evaluating compliance to a low glycaemic index (GI) diet in women with polycystic ovary syndrome (PCOS) by Egan N1, Read A, Riley P, Atiomo W.(PubMed)
(1253) Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines by Moran LJ1, Ko H, Misso M, Marsh K, Noakes M, Talbot M, Frearson M, Thondan M, Stepto N, Teede HJ.(PubMed)
(1254) Dietary substitutions for refined carbohydrate that show promise for reducing risk of type 2 diabetes in men and women. Maki KC1, Phillips AK2.(PubMed)
(1255) improved Excessive refined carbohydrates and scarce micronutrients intakes increase inflammatory mediators and insulin resistance in prepubertal and pubertal obese children independently of obesity by López-Alarcón M1, Perichart-Perera O2, Flores-Huerta S3, Inda-Icaza P4, Rodríguez-Cruz M1, Armenta-Álvarez A1, Bram-Falcón MT1, Mayorga-Ochoa M1.(PubMed)
(1256) the risk of Fast food fever: reviewing the impacts of the Western diet on immunity. Myles IA1.(PubMed)
(1257) The Small Rice Bowl-Based Meal Plan was Effective at Reducing Dietary Energy Intake, Body Weight, and Blood Glucose Levels in Korean Women with Type 2 Diabetes Mellitus. Ahn HJ1, Han KA, Kwon HR, Min KW.(PubMed)
(1258) Effect of meal frequency on blood glucose, insulin, and free fatty acids in NIDDM subjects. Bertelsen J, Christiansen C, Thomsen C, Poulsen PL, Vestergaard S, Steinov A, Rasmussen LH, Rasmussen O, Hermansen K.(PubMed)
(1259) Serum hyperglycemia might be not related to fat composition of diet and vegetable composition of diet might improve sugar control in taiwanese diabetic subjects by Hou YC1, Chang YL1, Kuo SC1, Chiang CF1, Chiang CY1, Lin YF1, Weng PC1, Hu FC1, Wu JH1, Lai CH2.(PubMed)
(1260) Genetic variation in the beta 3-adrenoreceptor gene (Trp64Arg polymorphism) and its influence on anthropometric parameters and insulin resistance under a high monounsaturated versus a high polyunsaturated fat hypocaloric diet by de Luis DA1, Aller R, Izaola O, Conde R, Eiros Bouza JM.(PubMed)
(1261) Protein: metabolism and effect on blood glucose levels by Franz MJ1.(PubMed)
(1262) DASH diet, insulin resistance, and serum hs-CRP in polycystic ovary syndrome: a randomized controlled clinical trial by Asemi Z1, Esmaillzadeh A2.(PubMed)
(1263) Diets containing traditional and novel green leafy vegetables improve liverfatty acid profiles of spontaneously hypertensive rats by Johnson M, Pace RD, Dawkins NL, Willian KR1.(PubMed)
(1264) Liver protein profiles in insulin receptor-knockout mice reveal novel molecules involved in the diabetes pathophysiology by Capuani B1, Della-Morte D2, Donadel G1, Caratelli S1, Bova L1, Pastore D1, De Canio M3, D'Aguanno S4, Coppola A1, Pacifici F1, Arriga R1, Bellia A5, Ferrelli F1, Tesauro M5, Federici M5, Neri A6, Bernardini S7, Sbraccia P5, Di Daniele N5, Sconocchia G8, Orlandi A9, Urbani A3, Lauro D10.(PubMed)
(1265) Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21 by Kim H1, Mendez R, Zheng Z, Chang L, Cai J, Zhang R, Zhang K.(PubMed)
(1266) Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice by Chang HP1, Wang ML, Chan MH, Chiu YS, Chen YH.(PubMed)
(1267) Regulation of carbohydrate metabolism by indole-3-carbinol and its metabolite 3,3'-diindolylmethane in high-fat diet-induced C57BL/6J mice by Poornima J1, Mirunalini S.(PubMed)
(1268) Indole-3 carbinol(Natural science comprehensive database)
(1269) The effects of legumes on metabolic features, insulin resistance and hepatic function tests in women with central obesity: a randomized controlled trial by Alizadeh M1, Gharaaghaji R2, Gargari BP3.(PubMed)
(1270) Dietary Patterns Are Associated with Metabolic Risk Factors in South Asians Living in the United States by Gadgil MD1, Anderson CA2, Kandula NR3, Kanaya AM4.(PubMed)
(1271) Chi Xiao Tou(Complementary and Alternative Healing University)

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