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Wednesday, December 9, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome:The Life Style Modification(Part II) In TCM

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

In Traditional Chinese Perspective

While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.

Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).

The Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term treatment of PCOs(1249).

6. Avoid soft drink(soda), sugar-sweetened fruit juice and energy drink
According to the article "An Unintended Consequence Of Diet Soda: Disrupting Friendly Bacteria And Raising Blood Sugar" by Faye Flam, diet Soda due to high content of artificial sweetener may disturb the internal ecosystem and raised blood sugar, thus defeating the purpose of these products by increasing risk for type 2 diabetes and obesity(1299).(See artificial sweetener for more information).
In a study of participants of 27,585 Japanese men and women aged 40-59 years who had no prior history of diabetes, intakes of soft drink was associated to increased risk of type 2 diabetes(1300).
Sugar-sweetened fruit juice, not 100% fruit juice is associated to risk of incidence of type 2 diabetes, according to 4 studies with a 191,686 participants, including 12,375 with type 2 diabetes(1301).
Energy drink has shown negatively effect on central nervous system, inducing jitteriness, nervousness, dizziness, the inability to focus, difficulty concentrating, and insomnia(1302) and heightened alertness, altered sleep patterns, arrhythmias and, rarely, seizures(1303).

7. Avoid milk and dairy products (cheese and yogurt)
According to traditional Chinese medicine, milk and dairy products are considered as "very cold and damp foods" in nature, as they can overload the digestive system, inducing production of phlegm, the main cause of PCOs(1304)(1305)(1306). Replacement of cow milk with (unsweetened)almond milk may contribute to many health aspects for women with PCOs. According to researches, almond milk not only be an efficacious substitute of cow milk in infant with cow-milk allergy/intolerance(1307) but also induces production of probiotics, which have a positive effect on fasting blood sugar(1310) and serum of insulin(1310) in in PCOS patients, through its fermentation stage(1308). According to the University of California at Davis, intake of almonds containing 31 g of total fat per day for 6 weeks had an beneficial effects on plasma lipids and androgens in PCOS(1309).

8. Moderate exercise (yoga, pilates, walking etc)
(See The General Approaches to prevent the unpreventable?)
[Moderate exercise not only increases blood flow to strengthen the body tissues(274)(275) and organs(276), including the reproductive system but also enhances the immunity(277) in fighting against inflammatory process(277)(278) due to irregular cell growth(281)(282) and foreign invasion(279)(280).]
[Yoga is a physical, mental, and spiritual practice in Hinduism, Buddhism.
According to studies holistic yoga therapy showed a significant effects in reducing anti-müllerian hormone (AMH-primary outcome), luteinizing hormone (LH), testosterone, hirsutism, and improving menstrual frequency, glucose, lipid, and insulin values(284) with nonsignificant changes in body weight, FSH, and prolactin in adolescent PCOS(283).]
In metabolic syndrome, a constellation of metabolic abnormalities, such as abdominal obesity, insulin resistance, an atherogenic dyslipidemia, elevated blood pressure, a prothrombotic profile, and inflammation(1311), physical exercise has shown to improve the lipid profile(1312). insulin resistance (IR)(1312) in obese boy and, bodyweight(1313), atherogenic lipid profiles(1313), insulin resistance(1313),blood pressure(1313) and anthropometric factors(1313) if used conjunction with standard diet therapy in Japanese population.

9. Lose some weight
Obsesity and particularly visceral fat excess in PCOs women have shown to involve stimulating ovarian androgen(1315) induced alternation of ovarian physiology(1314)(1315) associated with ovulatory disturbances(1314)(1315)and negative effects on the endometrium(1314) in contribution tofertility(1314), implantation failure(1314) and miscarriage(1314).
(Read more information of benefits of weight loss for women with PCOs inthe section PCOs in weight loss perspective)
The macro nutrients and Glycemic index
The Best PCOs Diets for weight loss
The Common Weight Loss Foods
The Common Weight Loss Herbs
The Weight Loss Vitamin C
The Weight Loss Vitamin D

10. Protect your Liver
Liver diseases such as nonalcoholic fatty liver disease (NAFLD) associated to 41% increased risk in women with PCOs(1320), is tightly associated with obesity and the metabolic syndrome induced physiopathology of fibrosis development and progression(1316) affecting the liver function not only in blood storing and formation(1318) and but also liver in transportation of blood and fluid to kidney and heart in fluid and blood distribution to our body(1318) and liver metabolism(carbohydrate metabolism (glycolysis and glycogen synthesis) and triglyceride synthesis (lipogenesis))(1319) in regulating insulin resistance associated with excessive fat accumulation in ectopic tissues, inflammation and endoplasmic reticulum stress(1317).
Vitamin B complex has shown to exhibit hepatoprotective effect(1321) through inhibition of lipid metabolic disorder)1321), oxidative damage(1321)(1322) and nitrosative stress(1322).
According to Auburn University, consumption of green leafy vegetables (GLVs) may reduce the risks associated with cardiovascular(1323) and liver diseases(1324) such as hepatocellular carcinoma(1324) through modulate liver fatty acid composition(1323).
Liver disharmony can contribute emotional depression(1318)(1324), exacerbating the psychological symptoms in women with PCOs(1325).

11. Weekly acupuncture
Suggestions of acupuncture for treatment of PCOs symptoms have been well established(1326)(1329)(1328), but larger example size and multi center studies are necessary to provide more reliable and valid scientific evidence(1336). Dr. Ren LN and research team said "acupuncture combined with Chinese herbal medicines or with moxibustion treatment have advantages in reducing serum luteinizing hormone/follicle-stimulating hormone (LH/FSH), insulin resistance (IR), testosterone (T), and body mass index (BMI)"(1327). Acupuncture has also shown to regulate menstrual dysfunction and induce ovulation in women with PCOs(1330).
In fact, acupuncture also lowers perceived stress at the time of embryo transfer for an improved pregnancy rate(1331), significantly reduce pain intensity and analgesic consumption during oocyte aspiration in IVF treatment(1332), occurrence of ovarian hyperstimulation syndrome (OHSS) in vitro fertilization and embryo transplantation(1333).....Combined with clomiphene, acupuncture effectively improves HCG day cervical mucus, endometrial thickness and morphology for a normal pregnancy(1334). The study by University of Adelaide preliminary data, suggested that acupuncture improves self-efficacy and psychological coping for women experiencing delays with falling pregnant(1335).
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(1247b) Polycystic Ovary Syndrome - a TCM Perspective by Donna Dupre, L.Ac.
(1248) Spleen-yang-deficiency patients with polycystic ovary syndrome have higher levels of visfatin by Fu H, Qiu Y, Xia M, Wei F, He H, Yang L.(PubMed)
(1249) PCOS – A Chinese Medicine Diet and Lifestyle Approach by Angela Warburton
(1299) n Unintended Consequence Of Diet Soda: Disrupting Friendly Bacteria And Raising Blood Sugar" by Faye Flam(Forbes)
(1300) Soft drink, 100% fruit juice, and vegetable juice intakes and risk of diabetes mellitus by Eshak ES1, Iso H, Mizoue T, Inoue M, Noda M, Tsugane S.(PubMed)
(1301) Intake of fruit juice and incidence of type 2 diabetes: a systematic review and meta-analysis by Xi B1, Li S1, Liu Z1, Tian H1, Yin X1, Huai P2, Tang W3, Zhou D4, Steffen LM3.(PubMed)
(1302) Energy drinks: a new health hazard for adolescents by Pennington N1, Johnson M, Delaney E, (PubMed)
(1303) Health risks of energy drinks: what nurses and consumers need to know by Guilbeau JR1.(PubMed)
(1304) Osteoporosis and Chinese Diet by Jacqueline (Australia)(Chinese holistic Health Exercise)
(1305) Chinese Medical Theory and Dairy Foods(Ask my Acupuncturist)
(1306) TCM Dietary Recommendations(Okanagan Acupuncture Centre)
(1307) The almond milk: a new approach to the management of cow-milkallergy/intolerance in infants by Salpietro CD1, Gangemi S, Briuglia S, Meo A, Merlino MV, Muscolino G, Bisignano G, Trombetta D, Saija A.(PubMed)
(1308) Development of a non-dairy probiotic fermented product based onalmond milk and inulin by Bernat N1, Cháfer M2, Chiralt A2, González-Martínez C2.(PubMed)
(1309) Differential effects of walnuts vs almonds on improving metabolic and endocrine parameters in PCOS by Kalgaonkar S1, Almario RU, Gurusinghe D, Garamendi EM, Buchan W, Kim K, Karakas SE.(PubMed)
(1310) Effects of Probiotic Supplementation on Pancreatic β-cell Function and C-reactive Protein in Women with Polycystic Ovary Syndrome: A Randomized Double-blind Placebo-controlled Clinical Trial by Shoaei T1, Heidari-Beni M1, Tehrani HG2, Feizi A3, Esmaillzadeh A1, Askari G1.(PubMed)
(1311) Abdominal obesity, insulin resistance, and the metabolic syndrome: contribution of physical activity/exercise by Ross R1, Després JP.(PubMed)
(1312) Adiponectin and markers of metabolic syndrome in obese children and adolescents: impact of 8-mo regular physical exercise program by Nascimento H1, Costa E1, Rocha S1, Lucena C2, Rocha-Pereira P3, Rêgo C4, Mansilha HF5, Quintanilha A6, Aires L2, Mota J7, Santos-Silva A1, Belo L1.(PubMed)
(1313) Ezetimibe combined with standard diet and exercise therapy improves insulin resistance and atherosclerotic markers in patients with metabolicsyndrome by Ohbu-Murayama K1, Adachi H2, Hirai Y1, Enomoto M1, Fukami A1, Obuchi A1, Yoshimura A1, Nakamura S1, Nohara Y1, Nakao E1, Umeki Y1, Fukumoto Y1.(PubMed)
(1314) [Obesity and polycystic ovary syndrome: reproductive issues].[Article in French] by Dewailly D1.(PubMed)
(1315) Metabolic effects of obesity on reproduction by Pasquali R1, Gambineri A.(PubMed)
(1316) Fibrosis in Nonalcoholic Fatty Liver Disease: Mechanisms and Clinical Implications by Angulo P1, Machado MV2, Diehl AM2.(PubMed)
(1317) Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link? by Asrih M1, Jornayvaz FR2.(PubMed)
(1318) Liver, Wood(The 5 Organs Network of Chinese Medicine - Liver)
(1319) Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver by Dentin R1, Girard J, Postic C.(PubMed)
(1320) Nonalcoholic fatty liver disease in women with polycystic ovary syndrome by Cerda C1, Pérez-Ayuso RM, Riquelme A, Soza A, Villaseca P, Sir-Petermann T, Espinoza M, Pizarro M, Solis N, Miquel JF, Arrese M.(PubMed)
(1321) [Protective mechanism of complex vitamin B and GSH on fatty liver]. [Article in Chinese] by Sun Y1, Dong Y, Wu J, Han Y.(PubMed)
(1322) Modulation of lecithin activity by vitamin-B complex to treat long term consumption of ethanol induced oxidative stress in liver by Das SK1, Vasudevan DM.(PubMed)
(1323) Diets containing traditional and novel green leafy vegetables improve liver fatty acid profiles of spontaneously hypertensive rats by Johnson M, Pace RD, Dawkins NL, Willian KR1.(PubMed)
(1324) Vegetable, fruit and antioxidant nutrient consumption and subsequent risk of hepatocellular carcinoma: a prospective cohort study in Japan by Kurahashi N, Inoue M, Iwasaki M, Tanaka Y, Mizokami M, Tsugane S.(PubMed)
(1325) Liver and Gallbladder Pattern Differentiation in Chinese Medicine(Sacred Lotud. Chinese medicine)
(1326) Personality profile in patients with polycystic ovary syndrome by Ozcan Dag Z1, Oguzturk O, Isik Y, Turkel Y, Bulcun E.(PubMed)
(1326a) Serum anti-Müllerian hormone and ovarian morphology assessed by magnetic resonance imaging in response to acupuncture and exercise in women with polycystic ovary syndrome: secondary analyses of a randomized controlled trial by Leonhardt H1, Hellström M, Gull B, Lind AK, Nilsson L, Janson PO, Stener-Victorin E.(PubMed)
(1327)[A meta-analysis on acupuncture treatment of polycystic ovary syndrome]. [Article in Chinese] by Ren LN, Guo LH, Ma WZ, Zhang R.(PubMed)
(1328) Combination of acupuncture and chinese medicinal herbs in treating model rats with polycystic ovary syndrome by Ma RJ1, Zhou J, Fang JQ, Yang DH, Qu F.(PubMed)
(1329) [Observation on therapeutic effect of acupuncture combined with chinese herbs on polycystic ovary syndrome of kidney deficiency and phlegm stasis type]. [Article in Chinese] by Shi Y1, Feng HJ, Liu HR, Zhu D.(PubMed)
(1330) Polycystic ovary syndrome: effect and mechanisms of acupuncture for ovulation induction by Johansson J1, Stener-Victorin E.(PubMed)
(1331) The relationship between perceived stress, acupuncture, and pregnancy rates among IVF patients: a pilot study by Balk J1, Catov J, Horn B, Gecsi K, Wakim A.(PubMed)
(1332) Auricular electro-acupuncture as an additional perioperative analgesic method during oocyte aspiration in IVF treatment by Sator-Katzenschlager SM1, Wölfler MM, Kozek-Langenecker SA, Sator K, Sator PG, Li B, Heinze G, Sator MO.(PubMed)
(1333) [Effect of electro-acupuncture on clinical outcomes and ovarian hyperstimulation syndrome in in vitro fertilization and embryo transplantation]. [Article in Chinese] by Hong YL1, Tan Y, Yin YY, Zou YJ, Guo YH, Nie XW.(PubMed)
(1334) [Infertility in polycystic ovary syndrome treated with acupuncture and clomiphene: a randomized controlled trial]. [Article in Chinese] by Jiang D, Zhang Y, Wu X, Wu S.(PubMed)
(1335) An exploratory study of the effect of acupuncture on self-efficacy for women seeking fertility support by Kovárová P1, Smith CA, Turnbull DA.(PubMed)
(1336) Acupuncture for infertility: is it an effective therapy? by Huang DM1, Huang GY, Lu FE, Stefan D, Andreas N, Robert G.(PubMed)

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