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Monday, December 28, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: TCM Herbal Medicine for Kidney Yang deficiency - Ren Shen

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).

PCOs Treatment according traditional Chinese medicine

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

Kidney yang deficiency

Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yang deficiency may also experience yang vacuity induced cold expressive syndrome, including
lumbago, cold limbs, fatigue, cold aversion, feverish sensation in chest, palms and soles(1573),
difficulty in urination, enuresis, incontinence, declining libido and edema(1574) as a result of kidneys no longer perform their function in store fluid to moister and warm the body for healthy function in the body's organs and tissues, inducing adrenal insufficient chronic lower back pain(1575)(1580), depression(1575), hypothyroidism(1579)(1575), nephritis(1578)(1575), ...(1575), leading to failure in transform damp heat expression, promoted accentuation of inflammatory development of phlegm(1583).
Kidney yang deficiency has shown to alter carbohydrate and lipid metabolisms (free fatty acids, 1-monolinoleoylglycerol, and cholesterol), gut microbiota metabolism (indole-3-propionic acid), indued anovulatory infertility( 1581) and hypertension(1582) of which related to symptoms of PCOs(1576)(1577).

Herbal medicine for kidney yang deficiency
5. Panax ginseng(Ren Shen)(1779)
Ren Shen is also known as Ginseng, panax ginseng. The smells aromatic, tastes sweet and slightly warm herbs had been used in TCM as improved immune system(1781)(1782), anti cancer(1783)(1784)(1785), anti aging(1786)(1787), anti stress(1788)(1789), antioxidant(1790)(1791), anti inflammatory(1792)(1793),...... agent and to generate body liquids and allay thirst(1794), treat
nervous disorders(1794)(1795)(1796), anemia(1797)(1798), dyspnoea(1799)(1800), forgetfulness(1801) and confusion(1802), decreased libido(1803)(1804), chronic fatigue(1805)(1806), angina(1807), nausea and vomiting(1808), it strongly tonifies original qi, the spleen and lungs, by enhancing the functions of spleen and lung channels(1780).

Chemical constituents(1779)(1780)
1. Saponins
2. Panaxynol
3. Ginsenyne
4. Alpha pansinsene
5. Beta pansinsene
6. Beta farnesene
7. Bicyclogermacrene
8. Beta elemene
9. Gama elemene
10. Alpha neodovene
11. Beta neodovene
12. Alpha humulene
13. Beta humulene
14. Ccaryophyllene
15. Beta gurjunene
16. Alpha gurjunene
17. Alpha selinene
18. Beta selinene
19. Gama selinene
20. Selin-4, alpha guaiene
21. Gama cubebene
22. Beta patchoulene
23. Hepatadecanol-1
24. Etc.

Epidemiological literature found in data base of PubMed also suggested that panax ginseng also processes anti metabolic syndrome(1809)(1810)(1811), through its effect on insulin resistance(1812)(1813), fasting blood glucose(1814)(1815), hyperglycemia(1816)(1817), hyperlipidemia(1818)(1819)(1820), hypertension(1821)(1822), weight control(1823) and obesity(1823)(1824)(1825), well as reducing risk of diabetes(1827)(1826)(1828) and cardiovascular disease(1829)(1830)(1831).
According to the research article dated 29 April 2014, the king of the herb has also found effectively for treatment of infertility of both sexes, including women with Polycystic ovary syndrome through lowering high numbers of antral follicles and increased the number of corpora lutea in the polycystic ovaries(1832).

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(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) by Liqin Zhao

(1779) Chinese Herbs – Ren Shen (Radix Ginseng) by Kyle J. Norton
(1780) ren shen (ginseng)(Complementary and Alternative Healing University)
(1781) Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System by Kang S1, Min H.(PubMed)
(1782) [Comparative study of main components of ginseng on immune function of rats]. [Article in Chinese] by Jia ZY, Xie X, Wang XY, Jia W.(PubMed)
(1783) Ginsenoside Rp1 from Panax ginseng exhibits anti-cancer activity by down-regulation of the IGF-1R/Akt pathway in breast cancer cells by Kang JH1, Song KH, Woo JK, Park MH, Rhee MH, Choi C, Oh SH.(PubMed)
(1784) In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng by Wang W1, Zhao Y, Rayburn ER, Hill DL, Wang H, Zhang R.(PubMed)
(1785) Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors by Hao M1, Wang W, Zhao Y, Zhang R, Wang H.(PubMed)
(1786) Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. Zhu J1, Mu X1, Zeng J2, Xu C1, Liu J1, Zhang M1, Li C1, Chen J3, Li T3, Wang Y1.(PubMed)
(1787) [Research of anti-aging mechanism of ginsenoside Rg1 on brain]. [Article in Chinese] by Li CP, Zhang MS, Liu J, Geng S, Li J, Zhu JH, Zhang YY, Jia YY, Wang L, Wang SH, Wang YP.(PubMed)
(1788) Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study by Rai D1, Bhatia G, Sen T, Palit G.(PubMed)
(1789) [The anti-stress effect of saponins extracted from panax ginseng fruit and the hypophyseal-adrenal system (author's transl)]. [Article in Chinese] by Zhang SC, Jiang XL.(PubMed)
(1790) Antioxidant effects of Panax ginseng C.A. Meyer in healthy subjects: a randomized, placebo-controlled clinical trial by Kim HG1, Yoo SR, Park HJ, Lee NH, Shin JW, Sathyanath R, Cho JH, Son CG.(PubMed)
(1791) Panax ginseng reduces oxidative stress and restores antioxidant capacity in aged rats by Ramesh T1, Kim SW, Hwang SY, Sohn SH, Yoo SK, Kim SK.(PubMed)
(1792) Panax ginseng C.A. Mayer G115 modulates pro-inflammatory cytokine production in mice throughout the increase of macrophage toll-like receptor 4 expression during physical stress by Pannacci M1, Lucini V, Colleoni F, Martucci C, Grosso S, Sacerdote P, Scaglione F.(PubMed)
(1793) Panax Potential analgesic and anti-inflammatory activities of Panax ginseng head butanolic fraction in animals by Lee JH1, Lee JH, Lee YM, Kim PN, Jeong CS.(PubMed)
(1794) Treatment with ginseng total saponins improves the neurorestoration of rat after traumatic brain injury by Hu BY1, Liu XJ2, Qiang R3, Jiang ZL4, Xu LH1, Wang GH1, Li X1, Peng B1.(PubMed)
(1795) [Advance in studies of Panax notoginseng saponins on pharmacological mechanism of nervous system disease]. [Article in Chinese] by Su P, Wang L, Du SJ, Xin WF, Zhang WS.(PubMed)
(1796) Neuroprotective effect of pseudoginsenoside-f11 on a rat model of Parkinson's disease induced by 6-hydroxydopamine by Wang JY1, Yang JY1, Wang F1, Fu SY1, Hou Y1, Jiang B1, Ma J1, Song C1, Wu CF1.(PubMed)
(1797) The haematopoietic effect of Panax japonicus on blood deficiency model mice by Zhang H1, Wang HF2, Liu Y3, Huang LJ3, Wang ZF4, Li Y5.(PubMed)
(1798) [Effect of Panax notoginsenosides on the proliferation of hematopoietic progenitor cells in mice with immune-mediated aplastic anemia]. [Article in Chinese] by Gai Y1, Gao RL, Niu YP.(PubMed)

(1799) Korean ginseng-induced occupational asthma and determination of IgE binding components by Kim KM1, Kwon HS, Jeon SG, Park CH, Sohn SW, Kim DI, Kim SS, Chang YS, Kim YK, Cho SH, Min KU, Kim YY.(PubMed)
(1800) [Acute massive pulmonary embolism in a patient using clavis panax]. [Article in Turkish] by Yüksel IO1, Arslan S, Cağırcı G, Yılmaz A.(PubMed)
(1801) Effect of Memo®, a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment by Yakoot M1, Salem A, Helmy S.(PubMed)
(1802) Evaluation of the ergogenic properties of ginseng: an update by Bahrke MS1, Morgan WR.(PubMed)
(1803) [Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia]. [Article in Italian] by Morgante G1, Scolaro V, Tosti C, Di Sabatino A, Piomboni P, De Leo V.(PubMed)
(1804) Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study by Oh KJ1, Chae MJ, Lee HS, Hong HD, Park K.(PubMed)
(1805) Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial by Kim HG1, Cho JH, Yoo SR, Lee JS, Han JM, Lee NH, Ahn YC, Son CG.(PubMed)
(1806) High-Dose Asian Ginseng (Panax Ginseng) for Cancer-Related Fatigue: A Preliminary Report by Yennurajalingam S1, Reddy A2, Tannir NM3, Chisholm GB4, Lee RT5, Lopez G5, Escalante CP6, Manzullo EF6, Frisbee Hume S2, Williams JL2, Cohen L5, Bruera E2.(PubMed)
(1807) 16 cases of coronary angina pectoris treated with powder composed of radix ginseng, radix notoginseng and succinum by Yuan J1, Guo W, Yang B, Liu P, Wang Q, Yuan H.(PubMed)
(1808) Effects of Korean red ginseng extract on cisplatin-induced nausea and vomiting by Kim JH1, Yoon IS, Lee BH, Choi SH, Lee JH, Lee JH, Jeong SM, Kim SC, Park CK, Lee SM, Nah SY.(PubMed)
(1809) Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study by Park BJ1, Lee YJ, Lee HR, Jung DH, Na HY, Kim HB, Shim JY.(PubMed)
(1810) Vinegar-processed ginseng radix improves metabolic syndrome induced by a high fat diet in ICR mice by Yun SN1, Ko SK, Lee KH, Chung SH(PubMed)
(1811) Traditional chinese medicine in treatment of metabolic syndrome by Yin J1, Zhang H, Ye J.(PubMed)
(1812) Amelioration of insulin resistance by Rk1 + Rg5 complex under endoplasmic reticulum stress conditions by Ponnuraj SP1, Siraj F1, Kang S1, Noh HY1, Min JW1, Kim YJ1, Yang DC1.(PubMed)
(1813) Improvement of insulin resistance by panax ginseng in fructose-rich chow-fed rats by Liu TP1, Liu IM, Cheng JT.(PubMed)
(1814) The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials by Shishtar E1, Sievenpiper JL2, Djedovic V1, Cozma AI1, Ha V1, Jayalath VH1, Jenkins DJ3, Meija SB1, de Souza RJ4, Jovanovski E1, Vuksan V3.(PubMed)
(1815) Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial by Oh MR, Park SH, Kim SY, Back HI, Kim MG, Jeon JY, Ha KC, Na WT, Cha YS, Park BH, Park TS1, Chae SW.(PubMed)
(1816) Anti-hyperglycemic effect of fermented ginseng in type 2 diabetes mellitus mouse model by Jeon WJ1, Oh JS, Park MS, Ji GE.(PubMed)
(1817) Anti-hyperglycemic effects of ginseng: comparison between root and berry by Dey L1, Xie JT, Wang A, Wu J, Maleckar SA, Yuan CS.(PubMed)
(1818) Anti-atherogenic action of panax ginseng in rats and in patients with hyperlipidemia by Yamamoto M1, Kumagai A.(PubMed)
(1819) Serum HDL-cholesterol-increasing and fatty liver-improving actions of Panax ginseng in high cholesterol diet-fed rats with clinical effect on hyperlipidemia in man by Yamamoto M, Uemura T, Nakama S, Uemiya M, Kumagai A.(PubMed)
(1820) Orally administered ginseng extract reduces serum total cholesterol and triglycerides that induce fatty liver in 66% hepatectomized rats by Cui X1, Sakaguchi T, Ishizuka D, Tsukada K, Hatakeyama K.(PubMed)
(1821) Effect of panax notoginseng saponins injection on the p38MAPK pathway in lung tissue in a rat model of hypoxic pulmonary hypertension by Zhao S1, Zheng MX, Chen HE, Wu CY, Wang WT.(PubMed)
(1822) Negligible pharmacokinetic interaction of red ginseng and antihypertensive agent amlodipine in Sprague-Dawley rats by Ryu SH1, Kim JW, Kim YS, Lee SH, Cho YB, Lee HK, Kim YG, Jeong WS, Kim KB.(PubMed)
(1823) Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model by Lim S1, Yoon JW, Choi SH, Cho BJ, Kim JT, Chang HS, Park HS, Park KS, Lee HK, Kim YB, Jang HC.(PubMed)
(1824) Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor by Karu N1, Reifen R, Kerem Z.(PubMed)
(1825) Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes by Han LK1, Zheng YN, Yoshikawa M, Okuda H, Kimura Y.(PubMed)
(1826) Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats by Lee HJ1, Lee YH, Park SK, Kang ES, Kim HJ, Lee YC, Choi CS, Park SE, Ahn CW, Cha BS, Lee KW, Kim KS, Lim SK, Lee HC.(PubMed)
(1827) Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat by Banz WJ1, Iqbal MJ, Bollaert M, Chickris N, James B, Higginbotham DA, Peterson R, Murphy L.(PubMed)
(1828) Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin by Liu Z1, Li W, Li X, Zhang M, Chen L, Zheng YN, Sun GZ, Ruan CC.(PubMed)
(1829) Ginseng extracts restore high-glucose induced vascular dysfunctions by altering triglyceride metabolism and downregulation of atherosclerosis-related genes by Chan GH1, Law BY, Chu JM, Yue KK, Jiang ZH, Lau CW, Huang Y, Chan SW, Ying-Kit Yue P, Wong RN.(PubMed)
(1830) Merit of ginseng in the treatment of heart failure in type 1-like diabetic rats by Tsai CC1, Chan P2, Chen LJ3, Chang CK4, Liu Z5, Lin JW4.(PubMed)
(1831) Ginseng is useful to enhance cardiac contractility in animals by Lin JW1, Cherng YG2, Chen LJ3, Niu HS4, Chang CK1, Niu CS4.(PubMed)

(1832) Herbal Ginseng and Infertility by Kyle J. Norton.

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