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Thursday, December 10, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: The Nutritional Supplements according to Traditional Chinese Medicine

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                    In Traditional Chinese Medicine Perspective
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

Dietary Suggestion, Life Style Modification and Nutritional Supplements according to TCM
According to Angela Warburton(1249), a doctor of Traditional Chinese Medicine practicing in Toronto, Canada, incorporating the proper dietary and lifestyle modifications, may make a BIG difference in the long-term for treatment of PCOs(1249).

Nutritional Supplements according to Traditional Chinese Medicine

Modern traditional Chinese medicine doctors may also recommend the list of nutritional supplements for management and treatment of PCOs, depending to differentiation.
1. Chlorophyll(Best for syndrome of Stagnation of Qi and blood stasis(1246) and Dampness heat of liver PCOs patients)
Chlorophyll, a water plant has been conferred to a wide range of health benefits, including anti cancers(1337)(1338), immune-modulating(1339), improve anemia(1341), anti hypoxia(1342), antioxidant(1343)(1340), anti inflammation(1344)(1345), etc. According to Lund University, thylakoids, achlorophyll-containing membranes in chloroplasts may constitute to weight loss over time, through its efforts in reduced food intake and prevented compensational eating later in the day(1345) and hypoglycaemia induced weight gain in overweight women(1345). "Chlorophyll processed a property in detoxification of the liver"(1346)(1347), according to Dr. Janet starr Hull of alternative health and nutrition said, of which improve liver function in cabohydrate and lipid metabolism.(see protect your liver in life style modification according to TCM for more information)
[Liver diseases such as nonalcoholic fatty liver disease (NAFLD) associated to 41% increased risk in women with PCOs(1320), is tightly associated with obesity and the metabolic syndrome induced physiopathology of fibrosis development and progression(1316) affecting the liver function not only in blood storing and formation(1318) and but also liver in transportation of blood and fluid to kidney and heart in fluid and blood distribution to our body(1318) and liver metabolism(carbohydrate metabolism (glycolysis and glycogen synthesis) and triglyceride synthesis (lipogenesis))(1319) in regulating insulin resistance associated with excessive fat accumulation in ectopic tissues, inflammation and endoplasmic reticulum stress(1317).
Vitamin B complex has shown to exhibit hepatoprotective effect(1321) through inhibition of lipid metabolic disorder(1321), oxidative damage(1321)(1322) and nitrosative stress(1322).
According to Auburn University, consumption of green leafy vegetables (GLVs) may reduce the risks associated with cardiovascular(1323) and liver diseases(1324) such as hepatocellular carcinoma(1324) through modulate liver fatty acid composition(1323).
Liver disharmony can contribute emotional depression(1318)(1324), exacerbating the psychological symptoms in women with PCOs(1325).]

2. Probiotics (the healthy bacteria found in your intestinal tract)
( Best for PCOs patient diagnosed with spleen yang deficiency(1248))
Foods promoted the growth of beneficial bacteria in the intestinal tract include whole grains, onions, bananas, garlic, honey, leeks, artichokes and some fortified foods, excluding milk and mlik products.
(See Avoid milk and dairy products (cheese and yogurt) in lyle style modification according to TCM for more information)
[According to traditional Chinese medicine, milk and dairy products are considered as "very cold and damp foods" in nature, as they can overload the digestive system, inducing production of phlegm, the main cause of PCOs(1304)(1305)(1306). Replacement of cow milk with (unsweetened)almond milk may contribute to many health aspects for women with PCOs. According to researches, almond milk not only be an efficacious substitute of cow milk in infant with cow-milk allergy/intolerance(1307) but also induces production of probiotics, which have a positive effect on fasting blood sugar(1310) and serum of insulin(1310) in in PCOS patients, through its fermentation stage(1308). According to the University of California at Davis, intake of almonds containing 31 g of total fat per day for 6 weeks had an beneficial effects on plasma lipids and androgens in PCOS(1309)].

According to studies, probiotics has shown to contrinute to many health aspects, including anti gastrointestinal diseases(1354)(1355)(1356) anti antibiotic(1348)(1349), anti antibiotic resistance(1350)(1351), improved immune(1352)(1353), anti diabetic(1357)(1358), anti obese(1359)(1360), anti metablic dysfunctional,(1361)(1362), antioxidant(1363), anti inflammatory(1364)(1365), anti cancerous(1366)(1367), anti infective activities, etc. In a study by Isfahan University and Isfahan University of Medical Sciences, probiotics also significantly improve serum insulin levels, among 72 women aged 15-40 years old diagnosed with PCOS in a randomized double-blind placebo-controlled clinical trial(1370).

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(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(1247b) Polycystic Ovary Syndrome - a TCM Perspective by Donna Dupre, L.Ac.
(1337) Chemopreventive potential of chlorophyllin: a review of the mechanisms of action and molecular targets by Nagini S1, Palitti F, Natarajan AT.(PubMed)(1338) Dietary chlorophyllin abrogates TGFβ signaling to modulate the hallmark capabilities of cancer in an animal model of forestomach carcinogenesis by Thiyagarajan P1, Kavitha K, Thautam A, Dixit M, Nagini S.(PubMed)
(1339)Pheophytin a and chlorophyll a identified from environmentally friendly cultivation of green pepper )enhance interleukin-2 and interferon-γ in Peyer's patches ex vivo by Pyo MY1, Park BK, Choi JJ, Yang )M, Yang HO, Cha JW, Kim JC, Kim IS, Lee HB, Jin M.(PubMed)
(1340) [The protective effect of chlorophyllin against oxidative damage and its mechanism].[Article in Chinese] by Zhang YL1, Guan L, Zhou PH, Mao LJ, Zhao ZM, Li SQ, Xu XX, Cong CC, Zhu MX, ZhaoJY.(PubMed)
(1341) Effects of sodium copper chlorophyllin on mesenchymal stem cell function in aplastic anemia mice by Yin LM1, Jiang HF, Wang X, Qian XD, Gao RL, Lin XJ, Chen XH, Wang LC.(PubMed)
(1342) [Antihypoxic effect of chlorophyllypt and the method for its clinical use in maternal and fetal tissue hypoxia].[Article in Ukrainian] by Shramkevych AF, Sol's'kyĭ IaP, Rozumenko MB.(PubMed)
(1343) Amelioration of radiation induced hematopoietic syndrome by anantioxidant chlorophyllin through increased stem cell activity and modulation of haematopoiesis by Suryavanshi S1, Sharma D1, Checker R1, Thoh M1, Gota V2, Sandur SK3, Sainis KB1.(PubMed)
(1344) Inhibitory effect of chlorophyllin on the Propionibacterium acnes-induced chemokine expression by Kang MS1, Kim JH, Shin BA, Lee HC, Kim YS, Lim HS, Oh JS.(PubMed)
(1345) Supplementation by thylakoids to a high carbohydrate meal decreases feelings of hunger, elevates CCK levels and prevents postprandialhypoglycaemia in overweight women by Stenblom EL1, Montelius C, Östbring K, Håkansson M, Nilsson S, Rehfeld JF, Erlanson-Albertsson C.(PubMed)
(1346) The Benefits of Chlorophyll (Dr.Janet Starr Hull)
(1347) Detoxification with Chlorella by Joy Healey BA(OU), DipION, MCTha, Qualified Nutritionist
(1348) [Probiotics for the treating acute diarrhea and preventing antibiotic-associated diarrhea in children].[Article in Spanish] by Pérez C1. (PubMed)(1349) The role of prebiotics and probiotics in pediatric diseases by Cardile S1, Alterio T, Arrigo T, Salpietro C.(PubMed)
(1350) Antibiotic resistance: the pros and cons of probiotics by Courvalin P1.(PubMed)
(1351) Antibiotic resistance and molecular characterization of probiotic and clinical Lactobacillus strains in relation to safety aspects of probiotics by Klein G1.(PubMed)
(1352) Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence by Frei R1, Akdis M, O'Mahony L.(PubMed)
(1353) Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions by Gourbeyre P1, Denery S, Bodinier M.(PubMed)
(1354) Therapeutic modulation of gut microbiota: current clinical applications and future perspectives by Ianiro G, Bibbò S, Gasbarrini A, Cammarota G1.(PubMed)
(1355) Probiotics in the gastrointestinal diseases of the elderly by Malaguarnera G1, Leggio F, Vacante M, Motta M, Giordano M, Bondi A, Basile F, Mastrojeni S, Mistretta A, Malaguarnera M, Toscano MA, Salmeri M.(PubMed)
(1356) A critical appraisal of probiotics (as drugs or food supplements) ingastrointestinal diseases by Passariello A1, Agricole P, Malfertheiner P.(PubMed)
(1357) Probiotics as beneficial agents on the management of diabetes mellitus: a systematic review by Razmpoosh E1, Javadi M1, Ejtahed HS2,3, Mirmiran P2.(PubMed)
(1358) Probiotics in Reducing the Risk of Gestational Diabetes by Isolauri E1, Rautava S, Collado MC, Salminen S.(PubMed)
(1359) Childhood obesity: immune response and nutritional approaches by Magrone T1, Jirillo E1.(PubMed)
(1360) [Role of probiotics in obesity management].[Article in Spanish] by Prados-Bo A1, Gómez-Martínez S1, Nova E1, Marcos A2.(PubMed)
(1361) The role of probiotics on each component of the metabolic syndrome and other cardiovascular risks by Miglioranza Scavuzzi B1, Miglioranza LH, Henrique FC, Pitelli Paroschi T, Lozovoy MA, Simão AN, Dichi I.(PubMed)
(1362) Prebiotic effects: metabolic and health benefits by Roberfroid M1, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, Wolvers D, Watzl B, Szajewska H, Stahl B, Guarner F, Respondek F, Whelan K, Coxam V, Davicco MJ, Léotoing L, Wittrant Y, Delzenne NM, Cani PD, Neyrinck AM, Meheust A.(PubMed)
(1363) Antioxidant status and hormonal profile reflected by experimental feeding of probiotics by Ghoneim MA1, Moselhy SS.(PubMed)
(1364) A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease by Kanai T1, Mikami Y, Hayashi A.(PubMed)
(1365) Anti-inflammatory and Intestinal Barrier-protective Activities of Commensal Lactobacilli and Bifidobacteria in Thoroughbreds: Role ofProbiotics in Diarrhea Prevention in Neonatal Thoroughbreds by Tanabe S1, Suzuki T1, Wasano Y1, Nakajima F2, Kawasaki H2, Tsuda T2, Nagamine N2, Tsurumachi T2, Sugaya K2, Akita H2, Takagi M3, Takagi K4, Inoue Y5, Asai Y5, Morita H6.(PubMed)
(1366) Probiotics as efficient immunopotentiators: translational role in cancerprevention by Shida K, Nomoto K1.(PubMed)
(1367) A potential role of probiotics in colorectal cancer prevention: review of possible mechanisms of action by Chong ES1.(PubMed)
(1368) Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents by Liévin-Le Moal V1, Servin AL.(PubMed)
(1369) Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta-analysis by Lv Z1, Wang B1, Zhou X1, Wang F1, Xie Y1, Zheng H2, Lv N1.(PubMed)
(1370) Effects of Probiotic Supplementation on Pancreatic β-cell Function and C-reactive Protein in Women with Polycystic Ovary Syndrome: A Randomized Double-blind Placebo-controlled Clinical Trial by Shoaei T1, Heidari-Beni M1, Tehrani HG2, Feizi A3, Esmaillzadeh A1, Askari G1.(PubMed)

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