Posted by Chantel Martiromo. research contributed by PubMed
In the study to examine the association between flavonoids, each flavonoid subclass
(except isoflavones) and the risk of breast cancer by conducting a
meta-analysis, posted in PubMed, indicated that twelve studies were included, involving 9 513 cases and 181 906 controls,
six of which were prospective cohort studies, and six were case-control
studies. We calculated the summary RRs of breast cancer risk for the
highest vs lowest categories of each flavonoid subclass respectively.
The risk of breast cancer significantly decreased in women with high
intake of flavonols (RR=0.88, 95% CI 0.80-0.98) and flavones (RR=0.83,
95% CI: 0.76-0.91) compared with that in those with low intake of
flavonols and flavones. However, no significant association of
flavan-3-ols (RR=0.93, 95% CI: 0.84-1.02), flavanones (summary RR=0.95,
95% CI: 0.88-1.03), anthocyanins (summary RR=0.97, 95% CI: 0.87-1.08) or
total flavonoids (summary RR=0.98, 95% CI: 0.86-1.12) intake with
breast cancer risk was observed. Furthermore, summary RRs of 3
case-control studies stratified by menopausal status suggested
flavonols, flavones or flavan-3-ols intake is associated with a
significant reduced risk of breast cancer in post-menopausal while not
in pre-menopausal women.
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