Posted by Chantel Martiromo. research contributed by PubMed
In a prospective cohort study to assess the relation between the intakes
of 26 flavonoids from 5 subclasses; flavonols, flavones, flavanones,
flavan-3-ols and anthocyanidins, and the risk of lung, prostate and
colorectal cancer,. posted in PubMed, showed thatduring the mean follow-up time of 16.2 years, 62 lung, 138 prostate, and
55 colorectal cancers occurred. All lung cancer cases occurred among
either current smokers (n = 50) or previous smokers (n = 12). After
adjustment for age, examination years, body mass index, smoking status,
pack-years of smoking, physical activity and intakes of alcohol, total
fat, saturated fat, fiber, vitamin C and E, relative risk (RR) for lung
cancer was 0.27 (95% CI: 0.11-0.66) for the highest quarter of total
flavonoid intake as compared with the lowest quarter. Out of 5 flavonoid
subclasses, flavonols and flavan-3-ols were associated with lung
cancer, for the highest quarter of intake the RR were 0.29 (95% CI:
0.11-0.78) and 0.24 (95% CI: 0.09-0.64), respectively. No association
between flavonoid intake and risk of prostate or colorectal cancer were
found. We conclude that high intake of flavonoids is associated with
decreased risk of lung cancer in middle-aged Finnish smoking men.
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