Posted by Chantel Martiromo. research contributed by PubMed
In a study to assess the relation between the intakes of twenty-six flavonoids from
five subclasses: flavonols, flavones, flavanones, flavan-3-ols and
anthocyanidins, and the mean common carotid artery intima-media
thickness (CCA-IMT), posted in PubMed, the mean intake of flavonoids was 128.5 (sd 206.7) mg/d and the mean
CCA-IMT was 0.78 (sd 0.17) mm. In the lowest quartile of total flavonoid
intake the non-adjusted mean CCA-IMT was 0.79 (sd 0.19) mm, while the
mean CCA-IMT was 0.76 (sd 0.15) in the highest quartile (P < 0.001).
After adjustment for age, variables related to CCA-IMT measurement,
history of atherosclerosis, smoking, BMI, diabetes, systolic blood
pressure, serum HDL- and LDL-cholesterol, VO2 max, and intakes of
alcohol, SFA, folate, vitamins C and E, the total flavonoid intake was
inversely associated with the mean CCA-IMT (P = 0.018). Out of different
flavonoid subclasses, flavan-3-ols were inversely associated with
CCA-IMT (P = 0.025) after statistical adjustment. There was a trend for
an inverse association between intake of flavonols and mean CCA-IMT (P =
0.055). We conclude that high intake of flavonoids is associated with
decreased carotid atherosclerosis in middle-aged Finnish men.
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