The Best Smoothie of Cooked Tomato, broccoli and Orange Juice for Prevention and Treatment of Albuminuria(proteinuria) in Focal segmental glomerulosclerosis

Kyle J. Norton(Scholar, Master of Nutrient, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Focal segmental glomerulosclerosis is scar tissues in the filtering unit of the kidney due to primary glomerular diseases in children and adolescents inducing edema and the loss of protein from the plasma into the urine. The syndrome may result of kidney failure when affected children and adolescents  grow into adulthood. According to Dr. Fogo AB, Focal segmental glomerulosclerosis (FSGS) has a common lesion in progressive kidney disease, and a disease characterized by marked proteinuria and podocyte injury(*).

The smoothie for prevention and treatment of proteinuria(albuminuria)

Yield: 2 servings (about 8 ounces each)

1 1/4 cups tomato

1/2 cup broccoli
1 cup organic orange juice

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of Albuminuria  has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Cooked Tomato, broccoli and Orange Juice may be the next generation of natural ingredients for prevention and treatment of Albuminuria due to kidney decline

Albuminuria is a medical condition with too much protein in the urine, found

typically inpatients with kidney diseases. According to the Brigham and Women's Hwayospital, higher derivative vitamin A, beta-carotene, intake may reduce risk for Glomerular Filtration Rate (GFR) decline(1).

Lycopene, a chemically a carotene, also exhibited anti nephrotoxicity through anti proinflammatory pathways(3),

Coenzyme Q10, antioxidant found abundantly in broccoli may prevent or minimize cyclosporine nephrotoxicity through its antioxidant effect(4).

Dr. Ishikawa A and Dr. Homma Y. professors a the the University of Tokyo said, "Ubiquinol, the reduced form of coenzyme Q10 ......an antioxidants, may have potential for preventing CyA nephrotoxicity"(5).

In type 2 diabetes model, intake of supplement of coenzyme Q10 exhibited anti renal mitochondrial dysfunction caused by diabetic induced nephropathy(6).

Free radical scavengers vitamin C (Orange)  intake, increased plasma and renal cortical vitamin C or E content in prevention of renal injury(7) and development of diabetic nephropathy(9).

According to the Yonsei University Wonju College of Medicine, vitamin C exhibited anti oxidative stress in ameliorated albuminuria and renal sclerosis in experimental diabetic rats(8).

The effectiveness of Cooked Tomato, broccoli and Orange Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Albuminuria with little or no adverse effects.

People who are at high risk of Albuminuria due to aging, weaken reno function... should drink at least one serving daily and women with Albuminuria should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary as overweight and obesity are well-established risk factors for cardiovascular disease and decline in kidney function(2) 

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References
(*) Causes and pathogenesis of focal segmental glomerulosclerosis by Fogo AB1.(PubMed)
(1) Associations of diet with albuminuria and kidney function decline. by Lin J1, Hu FB, Curhan GC.(PubMed)
(2) Association between body mass index and CKD in apparently healthy men by Gelber RP1, Kurth T, Kausz AT, Manson JE, Buring JE, Levey AS, Gaziano JM.(PubMed)
(3) Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene. Sahin K1, Tuzcu M, Sahin N, Ali S, Kucuk O.(PubMed)
(4) Effect of reduced form of coenzyme Q10 on cyclosporine nephrotoxicity by Sato T1, Ishikawa A, Homma Y.(PubMed)
(5) Beneficial effect of ubiquinol, the reduced form of coenzyme Q10, on cyclosporine nephrotoxicity by Ishikawa A1, Homma Y.(PubMed)
(6) Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes by Sourris KC1, Harcourt BE, Tang PH, Morley AL, Huynh K, Penfold SA, Coughlan MT, Cooper ME, Nguyen TV, Ritchie RH, Forbes JM.(PubMed)
(7) Effects of supplementation with vitamin C or E on albuminuria, glomerular TGF-beta, and glomerular size in diabetes by Craven PA1, DeRubertis FR, Kagan VE, Melhem M, Studer RK.(PubMed)
(8) Blockade of oxidative stress by vitamin C ameliorates albuminuria and renal sclerosis in experimental diabetic rats by Lee EY1, Lee MY, Hong SW, Chung CH, Hong SY.(PubMed)
(9) Effect of vitamin E and vitamin C supplementation on antioxidative state and renal glomerular basement membrane thickness in diabetic kidney by Kedziora-Kornatowska K1, Szram S, Kornatowski T, Szadujkis-Szadurski L, Kedziora J, Bartosz G.(PubMed)