The Smoothie of Green Tea, Coffee and Tomato for Prevention and Treatment of Liver Cancer(2)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Liver cancer
Yield: 2 servings (about 8 ounces each)
3/4 cup tomato
1/2 cup coffee
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of  Liver cancer has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by renowned institutions, conveyed that Green Tea(3), Coffee(4) and Tomato(7) may be holding a key for extracting natural ingredient for reduced early onset and treatment of Liver cancer.
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the Tohoku University Graduate School of Medicine, Regular comsumption of green tea is associated with a reduced risk of liver cancer incidence(1).

Liver cancer is defined as a condition of out of controlled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most liver cancer patient are diagnosed in the later stage of the cancer. According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide. Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

The Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University study in the review of nine prospective cohort articles involving 465,274 participants and 3694 cases of liver cancer from China, Japan, and Singapore, suggested that green tea exhibited a preventive effects on the risk for liver cancer in female Asian populations. However, additional studies are needed to make a convincing case for this association(2).

Epidemiologically, according to Dr. Fon Sing M and colleagues, consumption of green tea have an adverse relation with the onset of primary liver cancer(3).

Coffee is a brewed drink prepared from roasted coffee beans from the Coffee plant. According to the Japan Public Health Center-Based Prospective Study Group, regardless to hepatitis C (HCV) and B virus (HBV) infection, regular consumption may reduce the risk of liver cancer(4).In a prospective study in Japan, consisting 90,452 middle-aged and elderly Japanese subjects (43,109 men and 47,343 women) found that habitual coffee drinking may be associated with reduced risk of hepatocellular carcinoma (HCC)(5).

Dr. Petrick JL and the researchers at the The Liver Cancer Pooling Project convinced, coffee consumption is associated with reduced risk of HCC, particular in women(6).

Tomato is a red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house. Its phytochemical lycopene is found to associated to liver prevention used conjunction with the formula Sho-saiko-to, the Kagawa Medical University confirmed(7).In Obese animal model, dietary lycopene can prevent (High fat diet) HFD-promoted hepatocellular carcinoma (HCC) incidence and multiplicity in mice, depending on antibody gene BCO2 expression in elicited different mechanisms(8).

Furthermore, Apo-10'-lycopenoic acid (apo-10-lycac), a metabolite of lycopene, ameliorated the HFD-promoted hepatic tumorigenesis by in stimulating the cell survival mechanism of SIRT1 gene(9).

The finding of the effectiveness of Green Tea, Coffee and Tomato may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of  Liver cancer 

People who are at increased risk of Liver cancer , due to family history, auto immunity,....should drink the juices at least one a day. People with Liver cancer  should drink the juice as much as  as they can depending to digestive toleration.

Life style and diet pattern change are recommended.

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References
(1) Green tea consumption and the risk of liver cancer in Japan: the Ohsaki Cohort study by Ui A1, Kuriyama S, Kakizaki M, Sone T, Nakaya N, Ohmori-Matsuda K, Hozawa A, Nishino Y, Tsuji I.(PubMed)
(2) Green tea and liver cancer risk: A meta-analysis of prospective cohort studies in Asian populations. by Huang YQ1, Lu X2, Min H1, Wu QQ1, Shi XT1, Bian KQ1, Zou XP3.(PubMed)
(3) Epidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis by Fon Sing M1, Yang WS, Gao S, Gao J, Xiang YB.(PubMed)
(4) Effect of coffee and green tea consumption on the risk of liver cancer: cohort analysis by hepatitis virus infection status by Inoue M, Kurahashi N, Iwasaki M, Shimazu T, Tanaka Y, Mizokami M, Tsugane S; Japan Public Health Center-Based Prospective Study Group(PubMed)
(5) Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: a prospective study in Japan by Inoue M1, Yoshimi I, Sobue T, Tsugane S; JPHC Study Group(PubMed)
(6) Coffee Consumption and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Sex: TheLiver Cancer Pooling Project. by Petrick JL1, Freedman ND2, Graubard BI2, Sahasrabuddhe VV2, Lai GY3, Alavanja MC2, Beane-Freeman LE2, Boggs DA4, Buring JE5, Chan AT6, Chong DQ7,Fuchs CS8, Gapstur SM9, Gaziano JM10, Giovannucci EL11, Hollenbeck AR12, King LY6, Koshiol J2, Lee IM5, Linet MS2, Palmer JR4, Poynter JN13, Purdue MP14, Robien K15, Schairer C2, Sesso HD5, Sigurdson AJ2, Zeleniuch-Jacquotte A16, Wactawski-Wende J17, Campbell PT9, McGlynn KA2.(PubMed)
(7) Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of spontaneous liver cancer by Watanabe S1, Kitade Y, Masaki T, Nishioka M, Satoh K, Nishino H.(PubMed)
(8) Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice by Ip BC1, Liu C2, Ausman LM1, von Lintig J3, Wang XD4.(PubMed)
(9) Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice by Ip BC1, Hu KQ, Liu C, Smith DE, Obin MS, Ausman LM, Wang XD.(PubMed)