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Friday, May 20, 2016

Women Health: The Avocado, Carrot, Green Tea and Grape smoothie for Prevention and Treatment of Granulomatous mastitis

 Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The curable smoothie for reduced risk and treatment of  Granulomatous mastitis 
Yield: 2 servings (about 8 ounces each)
1/2 cup carrot
1/2 cup avocado
1/2 cup grape
1 cup green tea drink 1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Granulomatous mastitis is a very rare breast inflammatory disease of unknown etiology

The finding the natural ingredients for treatment of  Granulomatous mastitis  is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.
Recent reports from numbers of well known institutions insisted, intake of carrot(1) with high amount carotenoids, may be the next generation ingredient to be used on prevention and treatment of Granulomatous mastitis.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. Its phytochemical EGCG normalized LPS-induced low activities of antioxidant enzymes as well as decreased the high levels of inflammatory cytokine into the duct of mammary gland(1).
According to the Tufts University School of Medicine, green tea polyphenol epigallocatechin-3-gallate (EGCG), may also be beneficial in combinatorial treatments against active inflammatory breast cancer IBC disease or in maintenance regimens to avoid recurrence(2).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape may be effective in treatment of inflammatory breast disease through its antioxidant and anti-inflammatory properties(3).
According to the Northwestern University Medical School, "the expression of resveratrol anti-inflammatory, anti-platelet, and anti-carcinogenic effect through inhibited the binding of labeled estradiol to the estrogen receptor and it activated transcription of estrogen-responsive reporter genes transfected into human breast cancer cells"(4).
Vitamin derivatives α-tocopherol of vitamin E(avocado), retinol, and β-carotene of vitamin A(carrot) may be potential used a natural ingredients for treatment of inflammatory breast diseases through theirs reaction in different tissues and the genetic expression of inflammatory mediators, including breast cancer(5).
According to the Federal University of Viçosa, the effectiveness of vitamin E in ameliorated po inflammatory activities is due to its function of inflammatory mediators inh inhibition of cytokines IL-8, IL-10, and IFNγ(6).

The smoothie of Avocado, Carrot, Green Tea and Grape may hold a key in further studies in production of effective natural ingredients for prevention and treatment of any type of cystic breast disease without inducing adverse effects.

Women who are at increased risk of any of Granulomatous mastitis, due to family history,... should drink at least one cup daily. Women with any type of Granulomatous mastitis should drink no more than 4 serving daily depending to the digestive toleration.

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(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3.(PubMed)
(2) Epigallocatechin-3-gallate inhibits stem-like inflammatory breast cancer cells by Mineva ND1, Paulson KE, Naber SP, Yee AS, Sonenshein GE.(PubMed)
(3) Resveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3-dependent pathway by Alkhalaf M1, El-Mowafy A, Renno W, Rachid O, Ali A, Al-Attyiah R.(PubMed).
(4) Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor by Gehm BD1, McAndrews JM, Chien PY, Jameson JL.(PubMed)
(5) Antioxidant vitamins and cytokines are altered in breast cancer by Abranches MV1, Mendes MC, Pena Gd, Maia YC, Ribeiro SM, Franceschini Sdo C, de Paula SO, de Freitas RN, Peluzio MC.*(PubMed)
(6) Antioxidant vitamins and cytokines are altered in breast cancer by Abranches MV1, Mendes MC, Pena Gd, Maia YC, Ribeiro SM, Franceschini Sdo C, de Paula SO, de Freitas RN, Peluzio MC.(PubMed)

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