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Thursday, May 19, 2016

Women Health: The Smoothie of Black bean, Apple and Pomegranate for Reduced Complications and Treatment of Lysosomal Acid Lipase Deficiency (LALD)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Lysosomal Acid Lipase Deficiency (LALD)
Yield: 2 servings (about 8 ounces each)
3/4 cup black bean
3/4 cup apple
1 cup organic pomegranate juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of intrahepatic cholestasis of pregnancy has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Lysosomal Acid Lipase Deficiency (LALD) is a medical condition of metabolic storage disease of abnormal function of lysosomal Acid Lipase (LAL) enzyme in breakdown of certain lipids (fats) during pregnancy, leading to the accumulation of cholesteryl esters (CE) and triglycerides (TG) in lysosomes in some tissues.

Recent studies back by well known institutions proposed, kidney beans, apples, pears,barley and prunes with high amount of soluble fiber may be the next generation of natural ingredients for prevention and treatment of Lysosomal Acid Lipase Deficiency (LALD) through reduce the absorption of cholesterol into your bloodstream. According to NIH low cholesterol diet may benefit patients with Lysosomal Acid Lipase Deficiency (LALD)(1)

Black bean, an excellent dietary selection with no cholesterol, but a good source of protein and minerals is mall roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae. According to the joint study led by the Escuela de Biotecnología y Alimentos, Tecnológico de Monterrey, intake of black bean regularly may decrease hepatic lipogenesis and stimulatecholesterol excretion, in part, via bile acid synthesis(1), due to existence of its phytochemicals flavonoids and saponins(2).
Dr. Chávez-Santoscoy RA and professors at the Tecnológico de Monterrey-Campus Monterrey said,, in dose-dependent manner, "the content of flavonoids and saponins in black bean (Phaseolus vulgaris L.) seed coats extracts with a potential effect in loweringcholesterol absorption by the inhibition of cholesterol micellar solubility"(3).
Furthermore, phytosterols isolated from black bean, inhibited cholesterol micellar solubility and reduced the activation of the liver X receptor involved cholesterol metabolism, decreasing hepatic FAS expression and promoting hepatic β-oxidation of long-chain fatty acids metabolism(4).

Apple, one of the most widely cultivated tree fruits. is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae, native to Central Asia. According to the joint study led by the Dalhousie University, apple ignificantly improved blood lipid profiles in rats with diet-induced hyperlipidemia and LPS-induced acute inflammation when used conjunction with n-3 polyunsaturated fatty acid-rich fish oil(5).
Dr. Bouazza A and colleagues in the study of Vinegar antioxidant effect suggested, apple [Malus domestica Borkh. (Rosaceae)] vinegars expressed significantly reduction of cholesterol in high-fat diet (HFD)-induced hyperlipidemic Wistar rats(6), probably through its anti oxidative stress scavenging effects, in inhibition of lipid peroxidation, and increased the levels of antioxidant enzymes and vitamin(7).

Pomegranates is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran cultivated in Asian since ancient time. its pomegranate vinegar is found to exhibit a very significant (reduction in lipid profile level(6)
According to the Shaanxi Normal University, pomegranates ellagic acid (PEA) promoted cholesterol removal by enhancing fecal bile acid and up-regulation of the two pathways, LXR/PPAR-ABCA1(7).
Pomegranate juice antioxidant and hypocholesterolemic effects may also benefits patients with cardiovascular disease in reduced side effect of intake of statin(9).

The effectiveness of Black bean, Pomegranate, and Apple  may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced complications and treatment of . Lysosomal Acid Lipase Deficiency (LALD) with little or no adverse effects.

People who are at high risk of Lysosomal Acid Lipase Deficiency (LALD) due to family history .... should drink at least one serving daily and people with Lysosomal Acid Lipase Deficiency (LALD)should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary patter change are recommended.

References
(1) NINDS Acid Lipase Disease Information Page by (NIH)
(2) Flavonoids and saponins extracted from black bean (Phaseolus vulgaris L.) seed coats modulate lipid metabolism and biliary cholesterol secretion in C57BL/6 mice. by Chavez-Santoscoy RA1, Gutierrez-Uribe JA1, Granados O2, Torre-Villalvazo I2, Serna-Saldivar SO1, Torres N2, Palacios-González B2, Tovar AR2.(PubMed)
(3) Effect of flavonoids and saponins extracted from black bean (Phaseolus vulgaris L.) seed coats as cholesterolmicelle disruptors by Chávez-Santoscoy RA1, Gutiérrez-Uribe JA, Serna-Saldívar SO.(PubMed)
(4) Conjugated and free sterols from black bean (Phaseolus vulgaris L.) seed coats as cholesterol micelle disruptors and their effect on lipid metabolism and cholesterol transport in rat primary hepatocytes by Chávez-Santoscoy RA1, Tovar AR, Serna-Saldivar SO, Torres N, Gutiérrez-Uribe JA.(PubMed)
(5) Apple flavonols and n-3 polyunsaturated fatty acid-rich fish oil lowers blood C-reactive protein in rats with hypercholesterolemia and acute inflammation by Sekhon-Loodu S1, Catalli A2, Kulka M2, Wang Y2, Shahidi F3, Rupasinghe HP4.(PubMed)
(6) Effect of fruit vinegars on liver damage and oxidative stress in high-fat-fed rats by Bouazza A1, Bitam A1,2, Amiali M2, Bounihi A1, Yargui L3, Koceir EA1.(PubMed)
(7) Apple cider vinegar modulates serum lipid profile, erythrocyte, kidney, and liver membrane oxidative stress in ovariectomized mice fed high cholesterol by Nazıroğlu M1, Güler M, Özgül C, Saydam G, Küçükayaz M, Sözbir E.(PubMed)
(8) Effects of ellagic acid-rich extract of pomegranates peel on regulation of cholesterol metabolism and its molecular mechanism in hamsters by Liu R1, Li J, Cheng Y, Huo T, Xue J, Liu Y, Liu J, Chen X.(PubMed)
(9) [Addition of pomegranate juice to statin inhibits cholesterol accumulation in macrophages: protective role for the phytosterol beta-sitosterol and for the polyphenolic antioxidant punicalagin].[Article in Hebrew] by Rosenblat M1, Volkova N1, Aviram M1.(PubMed)

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