Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women", posted in US National Library of Medicine National Institutes of Health, indicated that Soy protein (60
g containing 45 mg isoflavones) given daily for 1 mo significantly (P
< 0.01) increased follicular phase length and/or delayed
menstruation. Midcycle surges of luteinizing hormone and
follicle-stimulating hormone were significantly suppressed during
dietary intervention with soy
protein. Plasma estradiol concentrations increased in the follicular
phase and cholesterol concentrations decreased 9.6%. Similar responses
occur with tamoxifen, an antiestrogen undergoing clinical trial as a
prophylactic agent in women at high risk for breast cancer. These
effects are presumed to be due to nonsteroidal estrogens of the
isoflavone class, which behave as partial estrogen agonists/antagonists.
The responses to soy
protein are potentially beneficial with respect to risk factors for
breast cancer and may in part explain the low incidence of breast cancer
and its correlation with a high soy intake in Japanese and Chinese women.
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