Posted by Chantel M. Contributed by US National
Library of Medicine National Institutes of Health
In a cross-sectional study in Asian Americans with breast cancer who were tamoxifen users (n = 380) to investigate the association between soy
intake and circulating levels of tamoxifen and its metabolites
(N-desmethyl tamoxifen [N-DMT], 4-hydroxytamoxifen [4-OHT], and
4-hydroxy-N-desmethyl-tamoxifen [endoxifen]), posted in US National Library of Medicine National Institutes of Health, indicated that Serum levels of tamoxifen or its metabolites were unrelated to self-reported intake of soy
or serum levels of isoflavones. Blood levels of tamoxifen were 81%
higher in postmenopausal women age 65 or older compared with
premenopausal women age 45 or younger (P = .005); similar patterns of
results were observed for the tamoxifen metabolites. Levels of N-DMT
were 27% (P = .03) lower among women in the highest tertile of body mass
index (BMI, > 24.4 kg/m2) compared with those in the lowest category
(BMI 21.5). Women who used hypertensive medications had higher levels
of tamoxifen (P = .02) and N-DMT (P = .04) compared with nonusers.
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