Posted by Chantel M. Contributed by US National
Library of Medicine National Institutes of Health
Pretreatment with a phytoestrogen genistein, a soy phytoestrogen has been shown to attenuate the development of pulmonary hypertension (PH). In the study of whether genistein could also reverse preexisting established PH and
prevent associated right heart failure (RHF). PH was induced in male
rats by 60 mg/kg of monocrotaline, posted in PubMed, researchers at the University of California Los Angeles School of Medicine, Department of Anesthesiology, showed that Genistein reversed right ventricular hypertrophy (right ventricular
hypertrophy index, 0.35±0.029 versus 0.70±0.080 in RHF), inhibited
neonatal rat ventricular myocyte hypertrophy, and restored PH-induced
loss of capillaries in the right ventricle. These improvements in
cardiopulmonary function and structure resulted in 100% survival by day
30. Genistein restored PH-induced downregulation of estrogen receptor-β expression in the right ventricle and lung.
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