Posted by Chantel M. Contributed by US National
Library of Medicine National Institutes of Health
Genistein, an isoflavone abundant in soy,
and icariin, a prenylated flavonol glycoside isolated from Epimedium
Herb, have both been identified to exert beneficial effects in
preventing postmenopausal bone loss,. In the study of Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro, posted in PubMed, researchers at the Lanzhou Command of CPLA, found that although future in vivo studies are required to investigate whether
icariin is more efficient in improving bone mass and/or preventing bone
loss, our in vitro studies have demonstrated that icariin has a stronger
osteogenic activity than genistein. In addition, while the prenyl group
on C-8 of icariin could be the active group that takes part in
osteoblastic differentiation and explains its greater potency in
osteogenesis, mechanisms of action, and reasons for the relative potency
of icariin versus genistein need to be further studied.
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