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Tuesday, February 25, 2014

Coffee and Endometrial cancer

Posted by Chantel Martiromo

The incidence of endometrial cancer among white women are higher in comparison of black women. According to the statistic, the risk of endometrial cancer among women is 1 in 7000. Every year, about 40,000 women in US are diagnosed with the disease. Women who carry certain mutation genes, such as  BRCA1 or the BRCA2 are associated to increased risk of endometrial cancer.

Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.

Coffee made from the roasted seeds of the genus Coffee, belonging to the family Rubiaceae native to southern Arabia. Strong evidence suggested that  drinking coffee reduced risk of endometrial cancer. The study of showed a correlation of caffeinated coffee intake associated with lower endometrial cancer risk among obese postmenopausal women(1) but the association with decaffeinated coffee remains unclear. In a prospective cohort study, conducted by the Harvard School of Public Health, Boston, indicated that Drinking of coffee, may reduce endometrial cancer risk, but addition of substantial sugar and cream to coffee could offset any potential benefits(2). The The National Institute of Environmental Medicine study also showed a positive effect of coffee in reduced risk of endometrial cancer, especially among women with excessive body weight(3).

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(1) Caffeinated coffee, decaffeinated coffee and endometrial cancer risk: a prospective cohort study among US postmenopausal women by Giri A1, Sturgeon SR, Luisi N, Bertone-Johnson E, Balasubramanian R, Reeves KW(PubMed)
(2) A prospective cohort study of coffee consumption and risk of endometrial cancer over a 26-year follow-up by Je Y1, Hankinson SE, Tworoger SS, De Vivo I, Giovannucci E(PubMed)
(3) Coffee drinking and risk of endometrial cancer--a population-based cohort study by Friberg E1, Orsini N, Mantzoros CS, Wolk A(PubMed)

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