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Sunday, February 23, 2014

Organic Soy and Endometrial Cancer

  Posted by Chantel Martiromo

The incidence of endometrial cancer among white women are higher in comparison of black women. According to the statistic, the risk of endometrial cancer among women is 1 in 7000. Every year, about 40,000 women in US are diagnosed with the disease. Women who carry certain mutation genes, such as  BRCA1 or the BRCA2 are associated to increased risk of endometrial cancer.

Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.

Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with suitable climate for commercial profit and a healthy foods.

Phytochemicals such as daidzein, genistein, or glycitein found in soy and other legumes have been speculated to reduce the risk of endometrial cancer and specially in lean women(1). According to the University of Hawaii Cancer Center, greater consumption of isoflavone-containing foods is associated with a reduced risk of endometrial cancer in nonhysterectomized postmenopausal women(2). In Estrogen-induced proliferation of endometrial epithelial cells, genistein found in legime and organic soy inhibited the proliferative effects of estrogen on endometrial adenocarcinoma cells presumably through activation of stromal cell ERβ(3). But In a total of 666 visits among 224 participants study conducted by University of Southern California, showed that there was no evidences to support of the effects of ISP supplementation onendometrial thickness or on the odds of endometrial hyperplasia and cancer in postmenopausal women(4).

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(1) Phytoestrogen consumption and endometrial cancer risk: a population-based case-control study in New Jersey by Bandera EV1, Williams MG, Sima C, Bayuga S, Pulick K, Wilcox H, Soslow R, Zauber AG, Olson SH(PubMed)
(2) Legume, soy, tofu, and isoflavone intake and endometrial cancer risk in postmenopausal women in the multiethnic cohort study by Ollberding NJ1, Lim U, Wilkens LR, Setiawan VW, Shvetsov YB, Henderson BE, Kolonel LN, Goodman MT(PubMed)
(3) Genistein effects on stromal cells determines epithelial proliferation in endometrial co-cultures by Sampey BP1, Lewis TD, Barbier CS, Makowski L, Kaufman DG(PubMed)
(4) Effect of isoflavone soy protein supplementation on endometrial thickness, hyperplasia, and endometrial cancer risk in postmenopausal women: a randomized controlled trial by Quaas AM1, Kono N, Mack WJ, Hodis HN, Felix JC, Paulson RJ, Shoupe D.(PubMed)

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