Whole grain and Endometrial Cancer

Depending to the stage and grade of the cancer, chemotherapy such as Doxorubicin, Cisplatin. Paclitaxel, Carboplatin, Topotecan may be necessary after surgery with certain side effects. Although epidemiological studies focusing the effective of vegetables and fruits in reduced risk and treatment of endometrial cancer with inconclusive results(1)(2)(3)(4), certain foods, through clinical studies have found to be effective in reduced risk and treatment of endometrial cancer with little or no side effect.
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle.
Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
Whole grain
It is suggested that whole grain reduced risk of endometrial cancer through its interaction of  sex hormone metabolism and body fat in a study of Cancer and Health cohort of 29,875 women aged 50-64 years at enrollment in 1993-1997(5).  Lignan, a chemical constituents found abundantly in whole-grain cereals, beans, berries, nuts, in animals has shown clear anticarcinogenic effects(6). A study of 23,014 Iowa women, aged 55-69 years in 1986 conducted by the University of Minnesota, indicated that an inverse association between whole grain intake and endometrial cancer and may protect against endometrial cancer among never-users of hormone replacement therapy(7). Also in a review of the literature, the University of Minnesota showed there is a striking consistency in reduced risk edometrial cancers associated with intake of whole grain(8).

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References
(1) Conference on "Multidisciplinary approaches to nutritional problems". Symposium on "Nutrition and health". Cruciferous vegetable intake and the risk of human cancer: epidemiological evidence BY Kim MK, Park JH(PubMed)
(2) Epidemiological studies on brassica vegetables and cancer risk by Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA(PubMed)
(3) Brassica vegetables and cancer prevention. Epidemiology and mechanisms by van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA.(PubMed)
(4) Fruits and vegetables and endometrial cancer risk: a systematic literature review and meta-analysis by Bandera EV, Kushi LH, Moore DF, Gifkins DM, McCullough ML(PubMed)
(5) Whole grain, dietary fiber, and incidence of endometrial cancer in a Danish cohort study by Aarestrup J¹, Kyrø C, Christensen J, Kristensen M, Würtz AM, Johnsen NF, Overvad K, Tjønneland A, Olsen A(PubMed)
(6) Lignans and human health by Adlercreutz H.(PubMed)
(7) Whole grain intake and incident endometrial cancer: the Iowa Women's Health Study by Kasum CM¹, Nicodemus K, Harnack LJ, Jacobs DR Jr, Folsom AR; Iowa Women's Health Study(PubMed)
(8) Whole grain intake and cancer: a review of the literature by Jacobs DR Jr¹, Slavin J, Marquart L(PubMed)