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Thursday, February 27, 2014

Fatty fish and endometrial cancer

Posted by Chantel Martiromo

The incidence of endometrial cancer among white women are higher in comparison to black. According to the statistic, the risk of endometrial cancer among women is 1 in 7000. Every year, about 40,000 women in US are diagnosed with the disease. Women who carry certain mutation genes, such as  BRCA1 or the BRCA2 are associated to increased risk of endometrial cancer.

Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.

Fatty fish containing a large amounts of omega-3 fatty acids may be associated to reduced risk of endometrial cancer, but not other types of fish, according to the nationwide case-control study in Sweden(1).The Ohio State University College of Medicine and the Fred Hutchinson Cancer Research Center study showed that long-chain ω-3 (n-3) polyunsaturated fatty acids (PUFAs), derived from marine sources, consisted a anti-inflammatory effect thus reducing risk of endometrial cancer, restricted to overweight and obese women(2). In the investigation of Tohoku University Graduate School of Medicine, the study indicated that  higher intake of vegetables, peanuts, fish, and boiled egg was associated with a reduced risk for EEA3). Unfortunately, some researchers suggested that there is evidence to support an association between meat or fish intakes or meat mutagens and endometrial cancer(4).

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(1) Associations of long-chain ω-3 fatty acids and fish intake with endometrial cancer risk in the VITamins And Lifestyle cohort by Brasky TM1, Neuhouser ML, Cohn DE, White E(PubMed)
(2) Food intake and the risk of endometrial endometrioid adenocarcinoma in Japanese women by Takayama S1, Monma Y, Tsubota-Utsugi M, Nagase S, Tsubono Y, Numata T, Toyoshima M, Utsunomiya H, Sugawara J, Yaegashi N(PubMed)
(3) A prospective investigation of fish, meat and cooking-related carcinogens with endometrial cancer incidence by Arem H1, Gunter MJ, Cross AJ, Hollenbeck AR, Sinha R(PubMed)
(4) Dietary factors and the risk of endometrial cancer: a case--control study in Greece by Tzonou A1, Lipworth L, Kalandidi A, Trichopoulou A, Gamatsi I, Hsieh CC, Notara V, Trichopoulos D(PubMed)

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