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Thursday, February 6, 2014

Phytochemical Piperine and allergic effect

Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system resistance against viruses and bacteria attacks.

The effects
In picryl chloride (PC)-induced ear swelling in PC sensitized mice, PN-ext exhibited its histamine release inhibitory activity, in vitro on compound 48/80-induced histamine release from rat peritoneal mast cells. Piperine (4.5 and 2.25 mg/kg) orally administered 5 times a week for 8 weeks in a murine model of asthma, showed an effectiveness in suppressed eosinophil infiltration, allergic airway inflammation and airway hyperresponsiveness  by induced the production of interleukin-4, interleukin-5(white blood cells expression), immunoglobulin E and histamine.

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(1) Histamine release inhibitory activity of Piper nigrum leaf by Hirata N, Naruto S, Inaba K, Itoh K, Tokunaga M, Iinuma M, Matsuda H.(PubMed)
(2) Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model by Kim SH, Lee YC.

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