Posted by Chantel Martiromo
The incidence of endometrial cancer among white women are higher in
comparison to black. According to the statistic, the risk of
endometrial cancer among women is 1 in 7000. Every year, about 40,000
women in US are diagnosed with the disease. Women who carry certain
mutation genes, such as BRCA1 or the BRCA2 are associated to increased
risk of endometrial cancer.
Endometrial cancer is a late adulthood cancer defined as a
condition of which the cells of the endometrial lining of uterus have
growth uncontrollable or become cancerous as a result of the alternation
of cells DNA. It's the fourth most common cancer among women overall,
after breast cancer, lung cancer, and bowel cancer.
Bufalin (Chan Su)
Bufalin is also known as toad venom. The acrid, warm, toxic herb
has been used in TCM to food poisoning with stomach pain and bloating,
vomiting, diarrhea, fainting, painful and swollen throat and certain
types of cancer, including liver cancer, intestine cancer, leukemia,
skin cancer etc. as it expels toxins, resolves oedema, calms pain, opens
the orifices, etc. by enhancing the functions of heart, kidney and
stomach channels. Bufalin, the cardioactive C-24 steroids was found to inhibit the growth of tumors of endometrium through cell
cycle arrest, apoptosis, and expression of genes proliferation
genes(28). The Oita University Faculty of Medicine study also showed
that Cang Su induced apoptosis through decreased the proportion of cells
in the S-phase and increased the proportion in the G0/G1 phases of the
cell cycle(29).
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A
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Sources
(28) Bufalin, a traditional oriental medicine, induces apoptosis in human cancer cells by Takai N1, Kira N, Ishii T, Yoshida T, Nishida M, Nishida Y, Nasu K, Narahara H.(PubMed)
(29) Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells by Takai N1, Ueda T, Nishida M, Nasu K, Narahara H.(PubMed)
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