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Monday, March 31, 2014

Ovarian Cancer and Aloe vera

  Posted by Chantel Martiromo

Ovarian cancer is defined as a condition of  abnormal ovarian cells growth of ovaries.  It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths.
Aloe vera
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herb studied in scientific ways with some conflicted results.
Aloe-emodin, a major compound of herbal Aloe Vera, in composition with Reih exhibited anti  human ovarian cancer SK-OV-3, effect in half inhibitory concentration (IC50)(7). Aloe-emodin (AE) alone, showed the effective in significant inhibition of  invasion, migration, and adhesion capacities of HO-8910PM cells(human ovarian cancer )(8). Aloin, a natural anthraquinone, extract from Aloe Vera, did not inhibit initiation of DNA synthesis and  cells replicated a full complement of DNA but had difficulty in M phase of cell cycle(9).
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References  

(7) Synthesis and anti-tumor activity evaluation of rhein-aloe emodin hybrid molecule by Yuan YF1, Hu XY, He Y, Deng JG.(PubMed)
(8) Inhibitory effect of aloe-emodin on metastasis potential in HO-8910PM cell line by He TP1, Yan WH, Mo LE, Liang NC.(PubMed)
(9) DNA ploidy and S phase fraction of breast and ovarian tumor cells treated with a natural anthracycline analog (aloin) by Esmat AY1, El-Gerzawy SM, Rafaat A.(PubMed) 

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