Posted by Chantel Martiromo
Ovarian cancer is defined as a
condition of abnormal ovarian cells growth of ovaries. It is one
of most common cancer in US, according to the statistics adapted from
the American Cancer Society's publication, Cancer Facts & Figures
2010, an estimated 21,880 women in the United States will be diagnosed
with ovarian cancer, causing 3,850 deaths.
Depending to the stage and grade of the cancer, chemotherapy such as
cisplatin, carboplatin, paclitaxel, liposomal doxorubicin may be
necessary to prevent the spread and recurrence of the cancer.
Epidemiological studies focusing in vegetables and fruits in reduced
risk and treatment of ovarian cancer have not been
conclusive(a)(b)(c)(d), some foods have showed to inhibit the
progression of cancer with little or no side effects.
Ginger (Zingiber officinale) or ginger root is the genus
Zingiber, belonging to the family Zingiberaceae, native to Tamil. It
has been used in traditional and Chinese medicine to treat dyspepsia,
gastroparesis, constipation, edema, difficult urination, colic, etc.
6-shogaol, a chmeical constituent isolated from ginger showed to
inhibited cell growth and modulated secretion of angiogenic factors in ovarian cancer
cells, through activation of NF-kappaB and and production of
VEGF(stimulation of vasculogenesis and angiogenesis) and
IL-8(Interleukin 8, a chemokine of the immune system)(8). In human A549,
SK-OV-3, SK-MEL-2, HCT15 tumor cells and the transgenic mouse ovarian cancer cell lines, 6-shogaol exhibited the most potent cytotoxicity against cell proliferation(9).
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(a) Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition by Schulz M1,
Lahmann PH, Boeing H, Hoffmann K, Allen N, Key TJ, Bingham S, Wirfält
E, Berglund G, Lundin E, Hallmans G, Lukanova A, Martínez Garcia C,
González CA, Tormo MJ, Quirós JR, Ardanaz E, Larrañaga N, Lund E, Gram
IT, Skeie G, Peeters PH, van Gils CH, Bueno-de-Mesquita HB, Büchner FL,
Pasanisi P, Galasso R, Palli D, Tumino R, Vineis P, Trichopoulou A,
Kalapothaki V, Trichopoulos D, Chang-Claude J, Linseisen J,
Boutron-Ruault MC, Touillaud M, Clavel-Chapelon F, Olsen A, Tjønneland
A, Overvad K, Tetsche M, Jenab M, Norat T, Kaaks R, Riboli E.(PubMed)
(b) Fruits and vegetables and ovarian cancer risk in a pooled analysis of 12 cohort studies by Koushik A1,
Hunter DJ, Spiegelman D, Anderson KE, Arslan AA, Beeson WL, van den
Brandt PA, Buring JE, Cerhan JR, Colditz GA, Fraser GE, Freudenheim JL,
Genkinger JM, Goldbohm RA, Hankinson SE, Koenig KL, Larsson SC,
Leitzmann M, McCullough ML, Miller AB, Patel A, Rohan TE, Schatzkin A,
Smit E, Willett WC, Wolk A, Zhang SM, Smith-Warner SA(PubMed).
(c) Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk by Riboli E1, Norat T.(PubMed)
(d) Risk of ovarian carcinoma and consumption of vitamins A, C, and E and specific carotenoids: a prospective analysis by Fairfield KM1, Hankinson SE, Rosner BA, Hunter DJ, Colditz GA, Willett WC.(PubMed)
(8) Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe by Kim JS1, Lee SI, Park HW, Yang JH, Shin TY, Kim YC, Baek NI, Kim SH, Choi SU, Kwon BM, Leem KH, Jung MY, Kim DK.(PubMed)
(9) Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe by Kim JS1, Lee SI, Park HW, Yang JH, Shin TY, Kim YC, Baek NI, Kim SH, Choi SU, Kwon BM, Leem KH, Jung MY, Kim DK.(PubMed)
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