Fritillaria cirrhose (Chuan Bei Mu) and Endometrial Cancer

  Posted by Chantel Martiromo

The incidence of endometrial cancer among white women are higher in comparison to black. According to the statistic, the risk of endometrial cancer among women is 1 in 7000. Every year, about 40,000 women in US are diagnosed with the disease. Women who carry certain mutation genes, such as  BRCA1 or the BRCA2 are associated to increased risk of endometrial cancer.
Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
Fritillaria cirrhose (Chuan Bei Mu)
Fritillaria cirrhose is a bulbous plants in the genus of Fritillaria belonging to the family Liliaceae, native to the Northern Hemisphere. The herb has been used in traditional Chinese medicine  as as antibiotic and to raise blood pressure, stop cough, , increased blood sugar,etc. as it transforms Phlegm, calms cough; clears Heat, dissolves nodules, etc. by enhancing the functions of heart and lung channels.
In the composition study of Scutellaria baicalensis (SB) and Fritillaria cirrhosa (FC), suggested that both herb inhibit the proliferation of endometrial cell line through activation of caspase-3(cell apoptosis) G₀ /G₁ phase cell cycle arrest, down regulation of cyclins D1 and D3(regulating cell cycle progression) and induction of p27(Cell cycle inhibition)(27)

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Sources 
(27) The Chinese herbs Scutellaria baicalensis and Fritillaria cirrhosa target NFκB to inhibit proliferation
 of ovarian and endometrial cancer cells by Kavandi L¹, Lee LR, Bokhari AA, 
Pirog JE, Jiang Y, Ahmad KA, Syed V.(PubMed)