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Friday, March 14, 2014

Endometrial Cancer In Vitamin B6 Perspective

Posted by Chantel Martiromo

The incidence of endometrial cancer among white women are higher in comparison of black. According to the statistic, the risk of endometrial cancer among women is 1 in 7000. Every year, about 40,000 women in US are diagnosed with the disease. Women who carry certain mutation genes, such as BRCA1 or the BRCA2 are associated to increased risk of endometrial cancer.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate  metabolism, brain health, and liver detoxification, etc.

Epidemiological studies linking vitamin B6 in reduced risk of endometrial cancer have been inconclusive, but the composition of vitamin B6 and other micro nutrient have found to be effective in some studies. One-carbon metabolism in 26 years of follow-up data from the Nurses' Health Study, do not appear to influence endometrial cancer incidence but showed protective effect for women with MTHFR 677 TT or MTHFR 1298 CC genotype(1) and a case of case-control study in Greece, indicated that intkae of Retinol, nicotinic acid, vitamin B- 6, and riboflavin  were  inversely associated with the disease(2).
But in a study between 1997 and 2003, 1,204 newly diagnosed endometrial cancer cases and 1,212 controls recruited among women between the ages of 30 and 69 years in urban Shanghai, China, showed dietary intake of vitamin B6 was not related to risk of endometrial cancer for women with enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), encoded by the MTHFR gene(3). Due to small size of some studies, some researchers suggested that large example size and multi centers studies are necessary to validate the effectiveness of any micro nutrient in endometrial cancer risk.

Taking altogether, without going into reviews, the composition of vitamin B6 and other micro nutrients may be effective in reduced risk and treatment of endometrial cancer. Over doses may induced the symptoms of difficulty coordinating movement, numbness, sensory changes, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.

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References
(1) One-carbon metabolism factors and endometrial cancer risk by Liu JJ1, Hazra A, Giovannucci E, Hankinson SE, Rosner B, De Vivo I.(PubMed)
(2)Diet in relation to endometrial cancer risk: a case-control study in Greece by Petridou E1, Kedikoglou S, Koukoulomatis P, Dessypris N, Trichopoulos D.(PubMed)

(2) Dietary folate intake, MTHFR genetic polymorphisms, and the risk of endometrial cancer among Chinese women by Xu WH1, Shrubsole MJ, Xiang YB, Cai Q, Zhao GM, Ruan ZX, Cheng JR, Zheng W, Shu XO.(PubMed)

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