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Tuesday, April 1, 2014

Ovarian Cancer and Herbal Ginseng

  Posted by Chantel Martiromo

Ovarian cancer is defined as a condition of  abnormal ovarian cells growth of ovaries.  It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States were diagnosed with ovarian cancer and 13,850 deaths.
Ginseng is a slow-growing perennial plants with fleshy roots, the genus Panax, belonging to the family Araliaceae. Depending to the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root). ginsenoside Rg3, a major chemical compound found in Ginseng, inhibited of SKOV-3 cell line through inhibition of tumor-induced angiogenesis and decrease of invasive ability and MMP-9(13).
Composition of ginsenoside Rg3 and cyclophosphamide CTX, significantly inhibited growth and angiogenesis of ovarian cancer(14). Ginsenoside Rh2, another chemical compound of the herb, inhibited the cancer cells through induction of apoptosis in addition to augmentation of the natural killer activity in spleen cells from tumor-hearing nude mice(15).  

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(13) Inhibitory effect of ginsenoside Rg3 on ovarian cancer metastasis by Xu TM1, Cui MH, Xin Y, Gu LP, Jiang X, Su MM, Wang DD, Wang WJ.(PubMed)
(14) Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer by Xu TM1, Xin Y, Cui MH, Jiang X, Gu LP.(PubMed)
(15) Inhibitory effects of ginsenoside Rh2 on tumor growth in nude mice bearing human ovarian cancer cells by Nakata H1, Kikuchi Y, Tode T, Hirata J, Kita T, Ishii K, Kudoh K, Nagata I, Shinomiya N.(PubMed)

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