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Wednesday, April 23, 2014

Herbal Sanguisorba officinalis and Skin Aging

Posted by Chantel Martiromo 

Skin aging is one of most visible process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin,  affected skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading  injuries damage regulation pathways of skin,  including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
The degradation of the epidermal and dermal layers of the extracellular matrix (ECM), the non-cellular component present within all tissues and organs, such as UV Exposure, decline of lysosomal/endosomal cathepsin K, S and V activity(c) as well as some environmental factors on skin produces visible signs such as irregular dryness, dark/light pigmentation, sallowness, severe atrophy, telangiectases, premalignant lesions, laxity, leathery appearance and deep wrinkling, etc.,  cause modification of the surface of skin and the physical properties of that lead to skin aging.
Certain chemical ingredients, such as aloin, ginsenoside, curcumin, epicatechin, asiaticoside, ziyuglycoside I, magnolol, gallic acid, hydroxychavicol, hydroxycinnamic acids, hydroxybenzoic acids, etc.  derived from herbs have been found to be intergraded  into some cosmetic products in treating premature aging(d).
Sanguisorba officinalis is a genus Sanguisorba, belonging to the family Rosaceae, native to throughout the cooler regions of the Northern Hemisphere. The herb has been used in folk medicine to stop bloody dysentery, nosebleeds, and topically to treat burns and insect bites.
Ziyuglycoside I isolated from a Sanguisorba officinalis root extract reduced skin aging through increased the expression of type I collagen in a dose-dependent manner(24). In chronic Ultraviolet-B (UVB) irradiation causes of skin aging, the extract of Sanguisorba officinalis L. inhibited wrinkle formation, maintained skin elasticity, and inhibited the decrease of dermal elastic fiber linearity in the rat hind limb skin in a dose-dependent manner(25). 

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References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(c) Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis by Sage J1, De Quéral D2, Leblanc-Noblesse E2, Kurfurst R2, Schnebert S2, Perrier E2, Nizard C2, Lalmanach G3, Lecaille F4.(PubMed)
(d) Bioactive compounds from natural resources against skin aging by Mukherjee PK1, Maity N, Nema NK, Sarkar BK.(PubMed)
(24) Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient by Kim YH1, Chung CB, Kim JG, Ko KI, Park SH, Kim JH, Eom SY, Kim YS, Hwang YI, Kim KH.(PubMed)
(25) Inhibitory effect of an extract of Sanguisorba officinalis L. on ultraviolet-B-induced photodamage of rat skin by Tsukahara K1, Moriwaki S, Fujimura T, Takema Y.(PubMed)

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