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Monday, April 7, 2014

Ovarian Cancer and Grape Seed Extract

  Posted by Chantel Martiromo

Ovarian cancer is defined as a condition of  abnormal ovarian cells growth of ovaries.  It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths.
Grape Seed Extract is the commercial extracts from whole grape seeds that contains many concentrations, including Resveratrol, vitamin E, flavonoids, linoleic acid, oligomeric proanthocyanidins(OPCs), etc..The herb has been used in traditional medicine as antioxidant, anti-inflammatory agents and to treat skin wounds with less scarring, allergies, macular degeneration, arthritis, enhance circulation of blood vessels, lower cholesterol, etc.
Resveratrol, a major compound found in grape seed extract showed to prevent Cisplatin-induced EMT in ovarian cancer cells, through increased cell death, and reduced the risk of metastasis(28). The
University of Michigan, in the study of the effects of Resveratrol in response of ovarian cancer cells, indicated that Resveratrol inhibits the growth and induces death in a panel of five human ovarian carcinoma cell lines, associated with mitochondrial release of cytochrome c, formation of the apoptosome complex, and caspase activation(29). The Seoul National University suggested that Resveratrol retards the growth of PA-1 cell xenograft and the expression of eEF1A2 (the gene may be critical in the development of ovarian cancer) in athymic nude mice(30).

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(28) Resveratrol Inhibits Cisplatin-Induced Epithelial-to-Mesenchymal Transition in Ovarian Cancer Cell Lines by Baribeau S, Chaudhry P, Parent S, Asselin E.(PubMed)
(29) Resveratrol-induced autophagocytosis in ovarian cancer cells by Opipari AW Jr1, Tan L, Boitano AE, Sorenson DR, Aurora A, Liu JR.(PubMed)
(30) Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target by Lee MH1, Choi BY, Kundu JK, Shin YK, Na HK, Surh YJ.(PubMed)

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